Award Data

This contract was awarded by the National Cancer Institute's Small Business Innovative Research (SBIR) and Small Business Technology Transfer (STTR) Program under the funding opportunity "Contract Topic: 277 Companion Diagnostics: Predictive and Prognostic Tests Enabling Personalized Medicine in Cancer Therapy."

DESCRIPTION (provided by applicant): Of all diseases, Tuberculosis (TB) represents one of, if not, the greatest health disparity between whites and minorities [1]. To be specific, for every TB-infected white person in the United States, there are an estimated 9 African-Americans, 8 Latinos, 6 Native Americans, 23 Asians, and 21 Native Hawaiian/Pacific Islanders with this disease [2]. Compounded wi ...

DESCRIPTION (provided by applicant): Human Rhinoviruses (HRV) cause approximately one third of the 60 million cases of common cold each year in the US and therefore are one of the most economically important human diseases of developed countries. Although rhinoviruses are not generally considered killer viruses, more recent studies have shown that rhinoviruses are a significant source of hosp ...

DESCRIPTION (provided by applicant): Anastomotic failure is one of the most feared complications of gastrointestinal surgery due to the resultant morbidity and mortality. Failure of an anastomosis, or intestinal junction, can cause a spectrum of morbidities to the patient including local abscess formation - requiring procedural drainage, tumor recurrence, debilitating pain, dysfunctional defecatio ...

DESCRIPTION (provided by applicant): The purpose of this Small Business Innovation Research (SBIR) Phase I grant proposal is to highlight the steps that Danya International, Inc. (Danya), will take to develop Educating Adults About Children With Autism Spectrum Disorders (EACA), an educational training program for school personnel who regularly interact with children in grades 1 through 5 with aut ...

DESCRIPTION (provided by applicant): Almost all human diseases have at least some environmental component. Even well- established genetic disorders do not often become manifest until adulthood, indicating at least some external influence on the pathological phenotype. To increase awareness of gene-environment interactions in education, the applicant company, Edvotek, will research high school and ...

DESCRIPTION (provided by applicant): Due to technological advances and improvements in patient care the survival rate of the extremely low birth weight (ELBW) preterm infants has increased substantially, resulting in a significant increase in the number of patients with bronchopulmonary dysplasia (BPD). BPD has become a major public health problem with 7,000 to 10,000 new cases occurring each year ...

DESCRIPTION (provided by applicant): Exercise induced paradoxical vocal fold motion (EI-PVFM) is a condition which symptoms include breathing difficulty and stridor during exercise, particular in adolescent athletes. Because its symptoms mimic exercise induced asthma, it is often treated with asthmatic medications. Poor response of EI-PVFM to these medications results in increased dosage and compl ...

DESCRIPTION (provided by applicant): The recent creation of human induced pluripotent stem cells (iPSC) from reprogrammed or de-differentiated adult cells has changed the approach and attitude of many to pluripotent stem cell research. These new iPSC are potentially a valuable source of in vitro models of complex, polygenic human diseases. They may find an important role in the discovery of new dr ...

DESCRIPTION (provided by applicant): New substances are routinely screened by pharmaceutical companies for their biological toxicity but failure to predict the toxicity of compounds to humans is a major financial cost for the pharmaceutical industry. In vivo multigeneration studies are expensive, laborious, and time consuming. Alternatively, in vitro cellular models can be completed in substantial ...