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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Topic 378: mPROS: Mobile PRO-CTCAE Administration System for Post-Radiation Toxicities

    SBC: Intelligent Automation, Inc.            Topic: NCI

    The problems this contract is addressing include making it easy for patients to report toxicities after radiation therapy so that they can be timely and accurate and so that they can be incorporated into a medical database for use by medical professionals. This would allow the app to recommend (when appropriate), and for clinicians to intervene, with appropriate treatments and will lead to better ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 369: DRUG DELIVERY SYSTEM TO SAVE HEARING DURING PEDIATRIC CHEMOTHERAPY REGIMENS

    SBC: Otomagnetics, Inc.            Topic: NCI

    Our company has invented a magnetic drug delivery device that we intend to develop to enable prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin chemotherapy regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing loss in kids has a dramatic impact on the ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. TOPIC 363- Caregiver Buddy: Leveraging Standards to Help Cancer Caregivers and Clinicians

    SBC: CARE PROGRESS, LLC            Topic: NCI

    This research project seeks to create innovative software that aids cancer patient caregivers,by improving their ability to access patient information, communicate with clinicians, and provide peer support. We seek to leverage the insights of stakeholders and subject matter experts as well as industry standards to enhance a caregiver facing SmartPhone app and related software developed in Phase I ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. AMADEUS: Acute Marijuana Intoxication DetectionUsing Digital Markers

    SBC: Intelligent Automation, Inc.            Topic: NIDA

    NIH through NIDA solicits the research and development of digital markers for detection of marijuana intoxication and cognitive impairmentThe goal of this project is to identify the most appropriate among candidate digital markerscognitive and physiologicalto detect driving related impairments due to acute Marijuana use and to develop a system consisting of wearablesa mobile appand accompanying ma ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. The purpose of this contract is to identify several cellular factors that have a major impact on production of a full-length HIV-1 envelope trimer without altering its native antigenic properties.

    SBC: CODEX BIOSOLUTIONS            Topic: NIAID

    million adults and more thanchildren become infected with HIV each yearAn effective HIV vaccine is a one time intervention that is extremely cost effective compared with the cost of lifelong treatmentThe classical vaccination approaches that have been successful in the control of various viral diseases by priming the adaptive immunity to recognize the viral envelope proteins have failed in the cas ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. The objective of this contract is to develop chemically modified mimics of microRNAs with improved activity and stability for the treatment of many diseases

    SBC: miRecule            Topic: NIAID

    Approximatelymillion people are currently living with human immunodeficiency virusHIVinfection worldwideWith no curative therapy on the horizonpatients must be on antiretroviral therapyARTfor decades to manage their diseaseBecause ART targets only actively replicating virustreatment interruption or ART failure leads to rebound of latent virusRNA therapeutics have shown great promise as a new mecha ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Vaccine Technologies and Strategies to Promote Sustained Vaccine Efficiency

    SBC: PROFECTUS BIOSCIENCES, INC.            Topic: NIAID

    The overarching objective of this proposal is the identification of novel vaccination regimen sleading to improved malaria vaccine efficacyThe medical need for such a vaccine remains compellingTo accomplish this goaltwo attenuatedheterologous viral vaccine vectorsrecombinant vesicular stomatitis virusrVSVand recombinant Isfahan virusrISFVabundantly expressing Plasmodium falciparum circumsporozoite ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. GENETIC CYTOLOGY FOR SURVEILLANCE OF RECURRENT BLADDER CANCER

    SBC: PAPGENE, INC.            Topic: NCI

    This proposal details the development of UroSeqS as a genetic cytology test to extend the utility of routinely collected urine specimens to the detection of recurrent bladder cancer UroSeqS is a genetic cytology assay that achieves sensitivity and specificity through identifying DNA mutations causative of cancer from routinely collected clinical specimens An innovative approach is used toanalyz ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. A Yeast based Immunotherapy against Clostridium difficile Infection

    SBC: FZATA INC            Topic: NIAID

    Abstract Antibacterial resistance is a global public health crisis Antibiotic resistant Clostridium difficile is responsible for more than deaths in US each year and the infection represents an urgent threat to public health worldwide Of most concern is that the incidence of C difficile infection CDI and disease severity is rapidly increasing in recent years due to the emergence of hy ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Evaluation of Natural Products and Derivatives as Antimalarial Agents

    SBC: Cascade Therapeutics, Inc.            Topic: NIAID

    PROJECT SUMMARY The proposed research focuses on the development of novel therapeutic agents for the treatment of malaria caused by P falciparum Preliminary studies have discovered some novel natural products and derivative molecules with potent in vitro activity against both sensitive and multidrug resistant malaria strains including the newly emerging artemisinin resistant parasite line New ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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