Award Data

The objective of this proposal is to develop enabling technology for the production of bulk scintillating nanocomposites that have gamma radiation detection properties of single crystal NaI but with the manufacturability of plastic scintillators. These performance criteria may be met by developing nanoparticle polymer composites with ultra-high nanoparticle loadings. These ‘ultra-composites’ w ...

Analysis of nuclear material samples in the field has many advantages over laboratory analysis. Laboratory analyses can be slow, involve increased expense, lead to additional waste generation and disposal problems, and may introduce errors due to sample degradation or mishandling. In situ analysis mitigates all of these problems. The specific aim of this project is the development of a truly por ...

DESCRIPTION (provided by applicant): It is widely accepted that the existing clinical paradigm of one treatment fits all is a major factor in the lack of progress in the effective treatment of a highly heterogeneous diseases. We propose a new innovative cl inical paradigm that optimizes brain cancer therapy using patient-specific markers of therapeutic response. Our long-term objective is to impro ...

DESCRIPTION (provided by applicant): Vestibular disorders represent a debilitating medical problem by causing balance and vision impairments that adversely affects the lives of people of all ages and backgrounds. The restoration of vestibular function by d irect stimulation of the vestibular nerve, bypassing the sensory organs, is expected to alleviate these symptoms in some patients. Currently, t ...

DESCRIPTION (provided by applicant): Iatrogenic nerve damage is one of the most adverse sequalae of tumor resection surgery in all parts of the body. Many neuromonitoring techniques have been developed to lower the incidence of damage, most notably electr ostimulation. However, the clinical potential of precise neuromonitoring remains unfulfilled, due to several key limitations intrinsic to elect ...

DESCRIPTION (provided by applicant): Advanced Medical Electronics seeks to develop a wearable device for the wireless acquisition of high-density surface-electromyogram (HD sEMG) signals. A new wireless networking standard called ultra-wideband (UWB) makes possible the creation of an ambulatory research HD sEMG instrument that can transmit 128 or more channels of data in real time. High-density s ...

DESCRIPTION (provided by applicant): This project will apply novel ultra-wideband (UWB) wireless impulse radio technology to provide connectivity from consumer electronics devices directly to micro- behind-the-ear (micro-BTE) hearing aids. In hearing aids, capturing sound close to the source before it is combined with background noise offers better signal to noise ratio. In the case of consumer e ...

DESCRIPTION (provided by applicant): A novel sulfonated polymer with unique chemically tailorable properties and processing characteristics has shown considerable promise as a thrombo- resistant surface and has been proven to be effective inhibitor against neutrophil- derived proteases. A phase 1 SBIR testing is proposed to investigate this polymer as a tailorable interface coating for blood-cont ...

DESCRIPTION (provided by applicant): Signal transduction systems regulate the majority of cellular activities including the metabolism, development, host-recognition, biofilm production, virulence, and antibiotic resistance of human pathogens. Thus, knowle dge of the proteins and interactions that comprise these communication networks is an essential component to furthering biomedical discovery. T ...

THE PURPOSE OF THIS GRANT IS TO SELECT APPROVABLE DRUGS FOR THE TREATMENT OF FOUR ORPHAN DISEASES: SICKLE CELL DISEASE,THALASSEMIA, HEMOCHROMATOSIS, AND ERYTHROPOIETIC PORPHYRIAS.FROM THE AVAILABLE WORLD MEDICAL LITERATURE ON THE FOUR DISEASES, DRUGS THAT ARE CLAIMED TO BE EFFECTIVE WILL BE EVALUATED AND CATEGORIZED AS TO THE EXTENT OF CLINICAL TESTING AND ANIMAL EXPERIMENTATION. THE THERAPEUTIC R ...