Award Data

Project SummaryAbstract Reia is working to address a prevalent gynecological conditionpelvic organ prolapsePOPwhich affects more thanof women over the age ofPOP occurs when the pelvic floor connective tissue and muscles weakenallowing the uterus or vaginal walls to descendIn extreme casesthe uterus descends through the opening of the vagina and hangs outside of the bodyPOP can be treated non surgi ...

This SBIR Phase II project aims to transform the lives and future economic opportunities of young people and their communities through democratized access to cross-curricular computer science, engineering, and cybersecurity education. Daily life, economies, innovation, and national security all depend on having a strong and skilled STEM workforce. For this workforce to exist, our schools must prov ...

PROJECT SUMMARYABSTRACT Older patients with persistent and progressive symptoms of chronic back pain and leg pain often have a diagnosis of lumbar degenerative spondyolisthesis and undergo complex lumbar decompression and fusion surgeryOverof these procedures are performed in the United States each yearSurgery is highly effective but technically challengingOne technical challenge of fusion in spon ...

Pathological hallmarks of Alzheimerandapos s diseaseADinclude extracellular deposits of Apeptidesintraneuronal aggregates of abnormally phosphorylated tau protein and neuroinflammationMost proposed AD disease modifying therapies have focused on strategies that reduce brain Aamyloid or tau pathological accumulationHoweversuch approaches have been unsuccessful in late stage AD clinical trials and ma ...

Aging Frailty is a biologically driven geriatric syndrome of multisystem physiological decline that is distinct from normal aging and disproportionately increases vulnerability to adverse clinical outcomesFrailty has an overall prevalence ofof thoseyears and olderand there is growing awareness in the geriatric community to diagnose and treat this conditionas it is not an inevitable consequence of ...

PROJECT SUMMARYCreare and its clinical and research partners propose to develop a software platformOnTRACKOnline Treatment Recovery Assistance for Concussion in Kidsfor children and adolescents recovering from concussion or mild traumatic brain injurymTBIThe platform includes a mobile applicationappfor the patients and their care teamparentsteacherscoachesetca database serverand a decision support ...

PROJECT SUMMARY Sclerodermasystemic sclerosisSScis an autoimmune disease of unknown etiology that is characterized by vascular dysfunctionfibrosisand inflammationOne in three patients dies withinyears of diagnosisgiving SSc the highest case fatality rate of any systemic autoimmune diseaseA lack of biologically relevant SSc disease models has created a critical unmet need for more efficient preclin ...

Increased competition and improved lead times are desired by the Defense Logistics Agency (DLA) for the MILSTAR system battery assembly. Mainstream Engineerings unique integration of engineering, manufacturing, quality control, and integrated logistics support (ILS) provides the government with the best value for the proposed NSN.The MILSTAR nickel-metal hydride battery pack lacks sufficient comme ...

Mentis Sciences Inc. (Mentis) proposes to develop a refurbishment program that is capable of disassembling, inspecting, and re-building complex systems and components, with the initial system of focus being the Minuteman Missile Antenna/Antenna Pedestal Assembly.To become a refurbishment supplier, Mentis will develop and adapt inhouse processes for performing refurbishment services by leveraging c ...

PROJECT SUMMARYAcute compartment syndromeACSremains one of the most devastating and often overlooked traumatic musculoskeletal disorders in clinical practiceIn this conditionpressure increases in one of the body s spacelimited compartmentsdue most commonly to direct trauma or bone fractureresulting ultimately in an ischemic injury to all of the compartment s contentsincluding muscle and nerveOnce ...