Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Linkage-specific ubiquitylation patterns as highly sensitive markers for neurodegenerative disease

    SBC: LIFESENSORS, INC.            Topic: NIA

    While sensitive imaging tools to detectamyloid and tau proteins and other biomarkers for established Alzheimer s diseaseADand other neurodegenerative diseases are availablesimilar tools for detecting presymptomaticetiologic biomarkers of these diseases are notAmong the earliest steps in AD is a failure of the ubiquitin proteasome pathway to respond to misfolded proteins by causing their degradatio ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a JBS HI-LO Urine DNA Kit

    SBC: JBS Science, Inc            Topic: 172

    Development of a JBS Hi Lo urine DNA kit There is a critical need for sensitive and cost effective technologies that can obtain high quality and comprehensive genomic data from easy to collect and handle human specimensCurrentlyfresh or frozen whole blood is the most commonly used source to obtain high quality and comprehensive genomic dataHoweverthe use of whole blood requires stringent collectio ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. High-throughput nanoMEA-based Proarrhythmia Assay

    SBC: Nanosurface Biomedical, Inc.            Topic: NHLBI

    PROJECT SUMMARY Failure of new drugs at late stages of development is an extremely costly event commonly associated with the detection of unexpected arrhythmogenic properties in novel drugs Undetected arrhythmia inducing effects are also a common reason for drug withdrawal from the market As a result the FDA now mandates that all new drugs be tested for potential arrhythmogenic properties which ha ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. STEM Interactive Digital Tool to Educate and Promote Hearing Health and Science for 4th to 7th Grade

    SBC: CREARE LLC            Topic: 500

    PROJECT SUMMARY ABSTRACT The National Research Council recognizes that serious computer games can support new inquiry based approaches to science instructionproviding virtual laboratories or field learning experiences that overcome practical and logistical constraints to student investigationsWith the nationally recognized need to encourage and enhance education in the ScienceTechnologyEngineering ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Ultra-High Content Analysis (UHCA) of Single Cells in Tissue: 60+ channel immunofluorescence labeling kits and companion imaging software for everyone

    SBC: Quantitative Imaging Systems, LLC            Topic: 102

    We propose to create a modular suite of products that will make highly multiplexed imaging of individual cells in intact tissue available to a wide range of laboratories through validated labeling kits and companion imaging software that promotes discovery through interactive image and data visualizationOur goal is to create a suite of integrated labelingdisplay and analysis products to elucidate ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Complex 3-Dimensional in vitro Human Skin Tissue Models for Scleroderma

    SBC: CELDARA MEDICAL, LLC            Topic: NIAMS

    PROJECT SUMMARY Sclerodermasystemic sclerosisSScis an autoimmune disease of unknown etiology that is characterized by vascular dysfunctionfibrosisand inflammationOne in three patients dies withinyears of diagnosisgiving SSc the highest case fatality rate of any systemic autoimmune diseaseA lack of biologically relevant SSc disease models has created a critical unmet need for more efficient preclin ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing

    SBC: Twinstrand Biosciences, Inc.            Topic: 102

    TBD

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Adaptable Pediatric Neurocognitive Assessment

    SBC: CREARE LLC            Topic: 103

    PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Development of CB1 Monoclonal Antibodies for Treating NASH

    SBC: INTEGRAL MOLECULAR, INC            Topic: 300

    ABSTRACT Nonalcoholic fatty liver diseaseNAFLDis the accumulation of intra hepatic lipids within hepatocellular lipid dropletsorhepatic steatosisHepatic steatosis can progress to nonalcoholic steatohepatitisNASHa chronic inflammatory condition that can lead to liver fibrosis and cirrhosisUnderlying factors associated with the development of NAFLD NASH include obesity and hyperlipidemiaNASH current ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a urine test for the early detection of liver cancer

    SBC: JBS Science, Inc            Topic: 102

    Development of a urine test for the early detection of liver cancer The need to develop an effective method for detecting liver cancer is urgentHCCa primary liver canceris the third leading cause of cancer deaths worldwide and the fastest rising cancer in USHCC has ayear survival rate of less thanif detected earlythe survival rate can be as high asThe survival rate drops significantlyhoweverto as ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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