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Development Commercialization of a Sensing Device to Detect Vaping Summary The use of e cigarettes or vaping has been steadily increasing since its introductionWhile potentially a tool to wean cigarette smokers from combustible tobaccoone consequence of the introduction of these devices has been the adoption of vaping by adolescentsWhile companies that offer vaping instruments for sale note that t ...

PROJECT SUMMARY ABSTRACT Opioid use disorderOUDand mortality from opioid overdose are significant public health concernsDeaths from opioid overdose are highly preventable with early detection and administration of naloxoneA key challenge of the epidemic is that overdose victims often die because they are alone or among untrained or impaired bystanders and thus do not receive timely resuscitationTh ...

Project Summary Age related kidney diseasesincluding chronic kidney diseaseCKDand acute kidney injuryAKIare major health problems and an economic burden worldwideIn the U Salonemillion people are affected by CKD diseasealthough the vast majority of these individuals are unaware of their conditionA coexisting diseasea new medicationor a surgical procedure can overstress the already compromised kidn ...

Project Summary Abstract The United States is in the midst of an opioid epidemicInmost recent estimatesmillion people met diagnostic criteria for opioid use disorderOUDIn that same yearAmericans died of opioid overdose an average ofpreventable deaths per dayOpioid agonist therapyOATsuch as buprenorphine naloxoneBUP NALcan reduce opioid overdose deaths by at leastdecrease opioid misuseand improve q ...

This Phase II effort prototypes a minimal volume microscope designed to allow for a 2-D digital holographic imaging concurrent with field of view spectral content at video frame rates. The use of a laser driven IR dual beam frequency comb, coincident with the optical beam path required for a digital holographic image, will allow rapid acquisition of both the spatial and the spectral content associ ...

Safe operation of the current Navy lighterage system can be performed in Sea State 3 and below. At present, sea state estimation is made by Navy personnel and is dependent on their level of experience.Creare is developing an automated Sea State Predictor (SSP) to provide a more accurate and reliable determination of the current sea state. The system relies on measurement of heave of the warping tu ...

Abstract Generation of human pluripotent stem cells upon reprogramming of patient-specific somatic cells and subsequent differentiation of the stem cells into more specialized cell types opened new exciting opportunities for human regenerative medicine. Direct reprogramming of fibroblasts to various cell types including neural cells and cardiomyocytes using different sets of bioactive factors was ...

With insulin being the only approved treatment of Typediabetes mellitusT DMthere is a very large unmet medical need for a definitive cure for pediatric and adult patientsIncrease in obesityunhealthy dietand physical inactivity are driving the prevalence of diabetes among all agesIn the U Sdiabetes currently affectsof the population of all agesand it is the seventh leading cause of deathwith an est ...

PROJECT SUMMARY A central mechanism of tumor drug resistance is the maintenance of tight junctions between malignant cells preventing penetration of molecules into the tumor microenvironment. We have generated junction openers (“JO”) that are small proteins that bind to desmoglein 2 (DSG2), a junction protein that is overexpressed in many cancers. Intravenous injection of JO increases tumor pe ...

The United States has a vast network of pipelines used for fuel transport. This infrastructure, installed in 1950–1970, is one of the largest in the world. Yet poor/missing records of the materials used, combined with the overall age and associated environmental degradation effects, often results in unsafe operation. Current non-destructive inspection techniques are only capable of detecting mat ...