Award Data

ImmuNext has defined an anti-MCT1 monoclonal antibody (mAb) that will be developed for the treatment of human autoimmune disease. The membrane monocarboxylate nutrient transporter SLC16A1 (MCT1) is a multi-pass transmembrane protein responsible for the facilitated transport of critical metabolites, including products of glycolysis: lactate, pyruvate and ketones. Our strong preliminary data support ...

DESCRIPTION provided by applicant Systemic lupus erythematosus SLE is a devastating autoimmune disease that most commonly affects women in their child bearing years SLE attacks multiple organ systems but renal and neurologic involvement are the usual harbingers of poor outcome Despite effective albeit toxic immunosuppressive therapy only of patients with these serious manifestations ...

DESCRIPTION (provided by applicant): This fast-track SBIR will result in a new type of software system, called V-Motive, which will facilitate the combination of two proven autism behavioral interventions: Applied Behavior Analysis therapy (ABA) and Video Modeling (VM). V-Motive will have the potential to change how ABA therapy is performed by making it feasible for therapy providers to leverage V ...

DESCRIPTION provided by applicant Today systemic sclerosis SSc clinical trials generally include all subsets some may benefit others do not confounding measures of efficacy Because each expression subset has a different underlying deregulated molecular pathway no single drug is expected to benefit all patients i e rational patient selection is required to facilitate drug development F ...

PROJECT SUMMARY Sclerodermasystemic sclerosisSScis an autoimmune disease of unknown etiology that is characterized by vascular dysfunctionfibrosisand inflammationOne in three patients dies withinyears of diagnosisgiving SSc the highest case fatality rate of any systemic autoimmune diseaseA lack of biologically relevant SSc disease models has created a critical unmet need for more efficient preclin ...

PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

PROJECT SUMMARY ABSTRACT The National Research Council recognizes that serious computer games can support new inquiry based approaches to science instructionproviding virtual laboratories or field learning experiences that overcome practical and logistical constraints to student investigationsWith the nationally recognized need to encourage and enhance education in the ScienceTechnologyEngineering ...

DESCRIPTION provided by applicant Hearing loss is a leading public health concern with about of American adults reporting some degree of impairment Of those fewer than seek help for their condition for a variety of reasons To address this issue the National Institue of Deafness and Other Communication Disorders NIDCD is seeking solutions to improve hearing healthcare access and l ...

DESCRIPTION provided by applicant The Principal Objective of this Fast Track SBIR project is to develop and validate a cost effective commercial product TheraSenseandquot a highly innovative active support surface bed system for the treatment and prevention of serious decubitus ulcers commonly known as bed sores or pressure ulcers Current advanced bed systems for both institutional and ho ...

DESCRIPTION (provided by applicant): The Center for Disease Control (CDC) estimates the yearly incidence of mild Traumatic Brain Injury (mTBI) at approximately 1.2 million cases in the United States alone. Approximately 1/3 of these injuries occur in football. The Principal Objective of this NIH Phase IIb SBIR project is to expand the utility of the current, and now commercially available, InSite ...