Award Data

The overall goal of the Phase II work is to advance novel tissue-integrating lactate sensors towards human testing as rapidly as possible (proposal does not include human testing itself). A single sensor injected subcutaneously can provide months of continuous physiological monitoring data transmitted wirelessly through near-infrared light for remote monitoring. This proposal includes activities s ...

Improved head and hearing protection is required for aircraft maintainers working on a carrier flight deck during launch and recovery operations. Legacy Flight Deck Cranials are inadequate in many aspects including hearing protection, impact protection, cleaning, comfort, and compatibility with night vision devices (NVDs) and with chemical, biological, and radiological (CBR) equipment. In this p ...

Hardware- and software-in-the-loop models offer an efficient and scalable approach for analysis of heterogeneous communication networks. A virtual laboratory that integrates a physical test-bed with a much larger simulated network, can incorporate realistic physical effects while simultaneously scaling the analysis to much larger networks than are realizable with a purely physical testbed. The e ...

Low resolution quality of operational data, size of objects of interest, view occlusions, and crowded scenes degrade the performance of state-of-art region saliency and object recognition approaches when applied to overhead sensor data. We have developed a technology to automatically detect and recognize multitude of objects of potential interest providing an object recognition decision with a hig ...

The U.S. Navy increases longevity of military platforms by upgrading key subsystems and components. Download of flight data has always been time consuming operation requiring participation of ground crew. POC offers a new download solution to efficiently transfer large amounts of flight data wirelessly with a seamless interface to the current flight data analysis software. At present, this data ...

Abstract In response to PA-15-065, the broad long-term goal of this project is to develop a portable radiation biodosimeter to be used at the point-of-care (POC) for assessing precise radiation exposure and susceptibility for acute radiation syndrome (ARS) within the first 7 days of exposure starting with ~250 µL of blood collected from a finger stick and a turnaround time (TAT) of less than 40 m ...

SummaryThe ultimate goal of our project is to develop novel therapeutics effective in chronic kidney diseases, such as diabetic nephropathy (DN), that normally develop fibrosis, lead to end stage renal disease and require renal replacement therapy. DN is a complication of diabetes and is characterized by thickening of the glomerular basement membrane and mesangial expansion, with progression into ...

DESCRIPTION (provided by applicant): In Phase I of this SBIR, ImmPORT Therapeutics and the UCI Proteomics Core developed a high throughput gene cloning and protein expression platform that allowed the proteomes of any sequenced infectious agent to be expre ssed and printed onto microarray chips. Since Phase I we have cloned and expressed ~15,000 genes from nearly 20 different pathogens associated ...

This SBIR Phase II project will manufacture and test under high power laser loading a full-scale DM matched to ABL requirements. This TRL 6 prototype will be 30 cm in diameter with 1.875 cm spaced actuators – identical to the current ABL DM. However, the new DM has 14 microns stroke compared to 8 microns currently and has a negligible thermal ripple of 0.006 microns peak-to-valley after 200 se ...

ImmuNext has defined an anti-MCT1 monoclonal antibody (mAb) that will be developed for the treatment of human autoimmune disease. The membrane monocarboxylate nutrient transporter SLC16A1 (MCT1) is a multi-pass transmembrane protein responsible for the facilitated transport of critical metabolites, including products of glycolysis: lactate, pyruvate and ketones. Our strong preliminary data support ...