Award Data

Sepsis is a poorly understood clinical syndrome and is characterized by a dysregulation of the immune system?s response to infection. It is the leading cause of death and is the most expensive condition treated in U.S. hospitals, exerting a $20.3 billion burden annually, 5.2% of total costs to the healthcare system nationwide. Sepsis is highly time critical and every 1-hour delay in antibiotics is ...

Polyfluoroalkyl and perfluoroalkyl compounds (PFCs) have been used commercially since the 1940’s due to their high level of chemical stability, almost frictionless surface or waterproofing characteristics. Elevated levels of PFCs have been linked to cancer and other health problems including reproductive and developmental risks. PFOA and PFOS are amongst the most prevalent of the PFCs with low l ...

PROJECT SUMMARY Diabetic retinopathyDRis a complication of diabetes and a leading cause of blindness in the worldAlthough it is widely accepted that DR is driven by ischemiathe current grading of DR severity is based only on structural alterations such as the presence of abnormal retinal microvasculature in non proliferative DR or angiogenesis in proliferative DRAs a resultmost patients have alrea ...

SummaryThis SBIR is to develop a pediatric widefield fundus cameraWFCfor non mydriatic examination of retinopathy of prematurityROPIn coordination with unique eye speculum based trans pars planar illuminatorthis pediatric WFC will be a low cost and portable device withfundus view in single shot imagesIt is known that ROP can affect periphery of the retinaand thus widefield fundus examination is es ...

PROJECT SUMMARYCreare and its clinical and research partners propose to develop a software platformOnTRACKOnline Treatment Recovery Assistance for Concussion in Kidsfor children and adolescents recovering from concussion or mild traumatic brain injurymTBIThe platform includes a mobile applicationappfor the patients and their care teamparentsteacherscoachesetca database serverand a decision support ...

SUMMARY The proposed research focuses on the use of neuroimaging and machine learning to detect and understand the progression of neurodegeneration caused by repetitive brain traumaand to differentiate this from that caused by Alzheimer s diseaseADand other dementiasThe deliverables defined in this Phase I stage will support the development of a commercial software product for use in pharmaceutica ...

Project Summary This Small Business Innovation Research Fast Track project aims to develop a wearable sensor system for hand hygiene compliance tracking and validate its efficacy through a pilot trial in clinical settingsHealthcareAssociated InfectionsHAIsare the most common type of complication for patients who are hospitalizedAccording to the Center for Disease Control and Preventioninthere were ...

ABSTRACT The economic burden of chronic pain in the U Sis staggeringIn the cases of medically refractory chronic neuropathic painneuromodulationsuch as spinal cord stimulationSCSand or dorsal root ganglionDRGstimulationis a non opioid based optionThough neuromodulation is typically electricalhere we examine an alternative with pulsed high intensity focused ultrasoundHIFUDelivering HIFU at lower do ...

PROJECT SUMMARY ABSTRACT Surefooted LLC is developing a novel type of physical therapy equipment with the potential to revolutionize fall preventionthe Surefooted TrainerTrainerinsenior citizens experience a fall each year and falls are the leading cause of death by an injury among those agedand olderCurrent treatments to prevent falls are inadequateThe Trainer consists of abyfoot platform with in ...

Pathological hallmarks of Alzheimerandapos s diseaseADinclude extracellular deposits of Apeptidesintraneuronal aggregates of abnormally phosphorylated tau protein and neuroinflammationMost proposed AD disease modifying therapies have focused on strategies that reduce brain Aamyloid or tau pathological accumulationHoweversuch approaches have been unsuccessful in late stage AD clinical trials and ma ...