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Project SummaryThe objective of our proposed research is to develop a water soluble molecule that can reduce the levels of amyloid betaAand Drpand prevent abnormal interactions between Aand Drpin Alzheimers diseaseADaffected neuronsOur previous AD studies foundincreased production and accumulation of Aand increased expression of Drpandan abnormal interaction between Aand Drpin AD neurons that was ...

PROJECT SUMMARY Developing an Automated Yeast Dissection System for Aging ResearchAging is the single greatest risk factor for diseases that are principal causes of mortalityThe objectives of aging research are to discover key genes and pathways related to aging that may eventually contribute to retardation of aging and a delay in the onset of age associated diseasesThe budding yeast Saccharomyces ...

In the USthe number of individuals agedand older will increase byover the next decadeConcurrentlyMedicare costs are expected to double to treat chronic diseases that will plague this increasing number of older adultsOne of the most wide spread chronic diseases that affects older adults is sarcopeniawhich is observed inof adults overyears of age andof adults overyears of ageThis disease is characte ...

TransWave Photonics, LLC proposes to develop mid-wave infrared photonic integrated circuits based on monolithic integration of passive low-loss waveguides, thermo-optically tunable photonic elements, and quantum cascade gain sections within the same InGaAs/AlInAs/InP platform. The proposed approach will enable power combining and 2-dimensinoal beam steering of the outputs from multiple high-power ...

We will develop a lab-on-chip optical absorption spectrometer spanning 3-15micron molecular fingerprint region, in a single epitaxially grown heterostructure that monolithically integrates thermally tuned distributed feedback quantum cascade laser (QCL) and quantum cascade detector (QCD) arrays with slotted photonic crystal waveguides (SPCWs) in a mid-infrared InGaAs passive photonic waveguide. In ...

Diode-Pumped Alkali Lasers (DPALs) have great potential for high-energy lasers. Proper design of these systems is challenging because many interrelated processes impact their performance, and critical kinetic rate coefficients are not well known. In response, our team is developing a comprehensive physics-based analysis/design tool, and experimentally determining key kinetic rate coefficients. The ...

There is a disconnect between the mission operation languages used by various NASA robots and by flight controllers or crew members. This disconnect unduly burdens mission operators, as it requires the involvement of expert robot programmers to define each activity. To eliminate this burden, we propose that robots in space (whether autonomous or remotely commanded by humans) should be commanded us ...

Americas current electronic warfare (EW) capabilities are insufficient for the modern and future battlefield. To safeguard against radio-controlled threats and disrupt enemy communications, our current EW systems blindly jam broad swaths of the electromagnetic spectrum (EMS). This approach interferes with Blue Force data and voice communications, requires large power sources and generates distinct ...

Liquid Rocket Engine (LRE) component manufacturing process by conventional processes are comprised of multi steps, components are fabricated by conventional machining from a forged or rolled billet/sheet. As a result a long lead time is needed and part acquisition time is high. So a low cost fabrication process is needed to replace current traditional processes. Low cost, rapid fabrication of this ...

Max-IR Labs LLC, in collaboration with UT Dallas, successfully demonstrated construction and operation of a prototype Infrared Near-Field Scanning Optical Microscopy (IR-SNOM) instrument for high-spatial-resolution thermal mapping of small heat sources, in particular Quantum Cascade Laser (QCL) facets, during Phase I.Preliminary data demonstrated feasibility of implementation of this instrument an ...