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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A collaborative data collection and analysis for inquiry-based experiential learning for health sciences related STEM education

    SBC: WICKED DEVICE LLC            Topic: 500

    Abstract The U SDepartment of Commerce predicts that STEMsciencetechnologyengineeringand mathjobs occupations will grow byfromtocompared tofor non STEM occupationsSTEM wages are generally higher than non STEMwith adifference inYetcurrent approaches to STEM education are falling significantly shortInof U Shigh school students underwent American College TestingACTOf theseonlyattained the benchmark o ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Activating latent growth factors for cartilage regeneration

    SBC: INNOVATIVE ELEMENTS, LLC            Topic: NIA

    Project summary Articular cartilage lesions are prevalent disorders affecting millions of AmericansDeprived of spontaneous healing capacitycartilage lesions may further deteriorate and lead to the onset of osteoarthritisOAOA represents a leading cause of chronic disabilities in the U Sand ultimately warrants total joint arthroplastyA common aspiration in orthopedic medicine is to regenerate the da ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. ADENOSINE DEAMINASE (ADA) AND PURINE NUCLEOSIDE PHOSPHORYLASE (PNP) DEFICIENCIES ARE ASSOCIATED WITH CERTAINIMMUNODEFICIENCIES IN HUMANS.

    SBC: Ert            Topic: N/A

    ADENOSINE DEAMINASE (ADA) AND PURINE NUCLEOSIDE PHOSPHORYLASE (PNP) DEFICIENCIES ARE ASSOCIATED WITH CERTAINIMMUNODEFICIENCIES IN HUMANS. ENZON WILL USE PATENTED METHODOLOGY TO PREPARE THERAPEUTIC MODIFICATIONS OF ADA AND PNP. THE PROCEDURE CONSISTS OF ATTACHMENT OF MONOMETHOXYPOLYETHYLENE GLYCOL (PEG) IN SUFFICIENT AMOUNTS TO ENZYMES TO PRODUCE CONJUGATES THAT ARE ESSENTIALLY NONIMMUNOGENIC AND S ...

    SBIR Phase I 1983 Department of Health and Human Services
  4. Adenylyl Cyclase Type 5 Inhibition to Treat Myocardial Infarction

    SBC: VASADE BIOSCIENCES, INC.            Topic: NHLBI

    PROJECT SUMMARY ABSTRACT The most significant advance in the treatment of Myocardial InfarctionMIhas been reperfusion therapywhich must be applied immediately after the MI diagnosis has been madeDespite the thousands of studies on drug therapies designed to reduce the size of the MImost have failed in clinical trialsOur hypothesis is that a major reason why these drugs failed is that they must be ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. A diabetes pill to replace insulin injections

    SBC: BIOORG3.14 LLC            Topic: 200

    The overall goal of this program is to develop an oral replacement for injecting insulinThe central premise of this work is that a small molecule called BGor similar moleculescan be taken orally in place of injecting insulin to aid in glycemic controlBGcould completely replace insulin injections or could reduce insulin injections by halfTo begin clinical testing to evaluate this premisea formalreg ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Advanced Dynamic Clamp for Neuroscience

    SBC: Cytocybernetics Inc            Topic: 101

    The goal of this proposal is to develop a commercial “plug and play”, user-friendly, powerful and reliable dynamic clamp system, to enable all neuronal electrophysiologists to be able to perform sophisticated dynamic clamp experiments, without any requirement for programming, engineering, or mathematical modeling skills. We will develop hardware and software specifically for neuroscience appli ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Agent Defeat using a DWA Accelerator

    SBC: BROOKHAVEN TECHNOLOGY GROUP INC            Topic: DTRA08008

    A new type of compact induction accelerator currently under development at the Lawrence Livermore National Laboratory (LLNL) promises to increase the average accelerating gradient by at least an order of magnitude over that of existing induction machines. The machine is based on the use of high gradient vacuum insulators and advanced dielectric materials and switches. The system, called the Diel ...

    SBIR Phase I 2008 Department of DefenseDefense Threat Reduction Agency
  8. Agonists of the RIG-I Innate Immune Pathway

    SBC: KINETA, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): There is a tremendous commercial demand for new antiviral products with novel mechanisms of action and which target a broad spectrum of viruses. Most previous and ongoing pharmaceutical development programs involve scre ening for inhibitors of essential virus enzymes with comparatively little investment in drugs that modulate the host immune response to infecti ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  9. Aminopterin for the Treatment of Severe Recalcitrant Atopic Dermatitis

    SBC: Syntrix Biosystems, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Atopic dermatitis (AD) is an itchy, inflammatory skin disease. It is one of the most common causes of human and canine disability. The incidence of human atopic dermatitis is steadily increasing. The mainstay of therapy for milder human disease is topical treatment. Patients with more severe disease suffer chronic itching and rash and often require systemic im ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  10. An adjuvant for an RSV prefusion F vaccine that safely protects infants via maternal vaccination

    SBC: Calder Biosciences Inc.            Topic: NIAID

    A Respiratory Syncytial VirusRSVvaccine is not yet availableAvatar is developing a noveldi tyrosine crosslinkedconformationally locked preF subunit immunogenDT preFthatformulated with an adjuvantwill form the basis of a preF RSV vaccineThe risk of vaccine enhanced diseaseVEDcame into sharp focus with the results of as formalininactivated RSV vaccine that resulted in numerous hospitalizations and t ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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