Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. TrachAlarm: A novel, low-cost accessory to automatically detect and alert caregivers to tracheostomy tube decannulation

    SBC: Innovations Unlimited LLC            Topic: NINR

    ABSTRACT The objective of the Phasegrant is to designdevelopand demonstrate feasibility of TrachAlarma novellow cost accessory to automatically detect and alert caregivers when a tracheostomy tube has become accidentally removed from the patientTracheostomy provides a criticallife supporting function for overmillion individuals in the United States with overnew procedures performed each yearEach o ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Native cell specific microenvironments for improved cell culture

    SBC: Xylyx Bio, Inc.            Topic: NHLBI

    PROJECT ABSTRACT East River BioSolutions is developing novel cell culture substrates aimed at improving predictive in vitro models of idiopathic pulmonary fibrosisIPFto empower the investigation of IPF pathobiology and to accelerate drug development and testing of new effective IPF drugsIPF is a devastatingintractableand life threatening interstitial lung disease characterized by obliteration of p ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Scalable Formulation and Production of Photosensitive Nanoparticles for Cancer Therapy

    SBC: POP Biotechnologies Inc.            Topic: 102

    PROJECT SUMMARY Up toof treated women with early stage breast cancer will suffer from local recurrences on the chest wallRCWTreatment of local recurrences is problematic and surgery provides only ayear control rateRadiation therapy is a preferred optionbut efficacy is low for larger lesionsandgtcm diameterand additional rounds of radiation therapy are associated with other long term risks due to c ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Validation of a novel, adjuvant implant for post-metastatic skeletal lesions

    SBC: ZETAGEN THERAPEUTICS, INC.            Topic: 102

    Project SummaryBone growth is critical to a favorable prognosis in thebreast cancer patients that have skeletal metastasesor approximatelypatients per year in the USLytic lesionsor voids in the boneresult from local bone destruction caused by tumor cell directedosteoclastic bone re absorption and lead to pathologic fracture and increased patient morbiditySurgical intervention is necessary to preve ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Feature Learning For Improved Multiplex Disease Diagnosis

    SBC: Deurion R&D LLC            Topic: 400

    Abstract This proposal is for CATTSa feature learning technique optimized for use in multiplex mass spectrometryMSfingerprinting assaysMS fingerprints consist of a large number of chemical speciesleading to very high dimensional feature spacesand subsequent high false discovery ratesCATTS aims to reduce the size of this spaceby using knowledge of the underlying biochemistryas well as general purpo ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Chemokine-receptor expression profiling in biological samples from human clinical trials

    SBC: Plumeria Therapeutics, Inc.            Topic: NINDS

    Project Summary AbstractChronic pain is a major healthcare burdenrepresenting economic costs of up to $B per yearmore than cancerdiabetesand heart diseasePain is a highly heterogeneous condition comprising neuropathicnociceptive and inflammatory componentsand patient responses to currently available drugs vary greatlyA very promising approach to target various forms of pain is through antagonism o ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Incorporation of a biofilm dispersion autoinducer into an antimicrobial ointment for the treatment of topical wounds

    SBC: EXCELSIOR BIOFILMS LLC            Topic: NIAID

    Project Summary Three species of biofilm forming bacteriaAcinetobacter baumanniiPseudomonas aeruginosa and Staphylococcus aureuswere recently identified by WHO as critical or high priority pathogens for which new antibiotics or antimicrobial treatments are urgently neededWe believe the inability to effectively prevent or treat a wide range of biofilm related chronic diseases may be overcome by usi ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Preclinical Development of HIV Vif Antagonists

    SBC: OYAGEN, INC.            Topic: NIAID

    SUMMARYThis revised application is for a Phase I SBIR grant under PAin which NIAID and DAIDS have expressed a special emphasis on thedevelopment of anti HIV agents directed at new viral or cellular targets for treatment of HIV infectionThe goal of our proposal is to address the call to evaluate novel drug targets by conducting preclinical studies for a first inclass antiretroviralARVtherapeutic fo ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. An adjuvant for an RSV prefusion F vaccine that safely protects infants via maternal vaccination

    SBC: Calder Biosciences Inc.            Topic: NIAID

    A Respiratory Syncytial VirusRSVvaccine is not yet availableAvatar is developing a noveldi tyrosine crosslinkedconformationally locked preF subunit immunogenDT preFthatformulated with an adjuvantwill form the basis of a preF RSV vaccineThe risk of vaccine enhanced diseaseVEDcame into sharp focus with the results of as formalininactivated RSV vaccine that resulted in numerous hospitalizations and t ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a Prototype FallsTalk- Caregiver Resource System

    SBC: Brookside Research & Development            Topic: NIA

    Falls are a common and expensive problemespecially in persons with dementiaPwDAnnual fall rates in PwD can be as high asInjurious falls are a frequent reason people are unable to stay in their homessignificantly increasing the costs of care to the family and societyFallers usually do not understand the cause of their fall and often repeat the same behaviorthe single best predictor of fall risk is ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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