Award Data

From HIV to metastatic cancer, state-of-the-art therapeutics are static biological or pharmaceutical compounds—whose efficacy is inevitably lost once their evolving disease targets sufficiently mutate. We engineered the first adaptive therapeutics designed to co-adapt with adapting disease agents—to provide ‘resistance-proof’ disease control. Known as Therapeutic Interfering Particles (‘ ...

Development of air vehicles capable of routine operation and able to achieve hypersonic speeds is paced by the availability of a propulsion system. The vision is to combine improved off-the-shelf turbines for low-speed operation (M=0 to 2+) and dual-mode ramjet (DMSJ) engine technologies for high-speed operation (M=2+ to 5+), with both engines sharing a common air inlet and a common thrust produci ...

During the phase I effort, Semandex Networks and its team designed and implemented a proof-of-concept cloud-based application for knowledge navigation and document discovery that combines powerful text analytics with an intuitive UI. The prototype capability is poised to transform current data archival systems into meaningful connected information. The proof-of-concept prototype developed during t ...

Unlike conventional computers, the embedded computers found in vehicles, routers and other Internet of Things devices lack the capability to have their software remotely updated. Vulnerabilities discovered in such devices remain unpatched, creating a large and growing attack surface. We propose to address this limitation in our Identification and Modification of Features in Embedded Devices (IMFED ...

Typically, the electro-optical Mach-Zehnder interferometric intensity modulator is the key optical component that determines the ultimate performance of an externally-modulated high-performance analog RF fiber-optic link. Intrinsically, the device has a symmetric structure and has a transmission peak at zero bias. In order to operate at the maximum linearity quadrature point, the optical symmetr ...

Based on promising results obtained under our Phase 1 SBIR contract, nLIGHT wishes to proceed with a Phase 2 program. In the proposed program, nLIGHT will continue the development of high power, single-lateral-mode tapered diode lasers. nLIGHT has identified fundamental limitations to the operation of tapered diode lasers and proposes novel design and fabrication process improvements which direc ...

Orora Design Technologies proposes to develop electronic design automation (EDA) tools employing minimally invasive circuit design-based methods to mitigate single event effects (SEEs) for next generation Ultra-DSM CMOS (

Field Programmable Gate Arrays (FPGAs) are an important technology for many DoD and commercial high performance computing applications. A number of supercomputing, workstation, and embedded computing hardware platforms have emerged recently to supply FPGA computing power for these applications. Unfortunately, developing for these platforms is currently a long, difficult and error-prone process. Wh ...

In Phase I of this effort we analyzed the structural response of a BLU 109 during typical penetration events. Based on these finite element results, we proposed and demsonstrated a simple robust concept for a passive penetrator sensor that identifies the material being penetrated and also correlates strongly with its underground trajectory. Such a sensor would obviously provide valuable informatio ...