Award Data

From HIV to metastatic cancer, state-of-the-art therapeutics are static biological or pharmaceutical compounds—whose efficacy is inevitably lost once their evolving disease targets sufficiently mutate. We engineered the first adaptive therapeutics designed to co-adapt with adapting disease agents—to provide ‘resistance-proof’ disease control. Known as Therapeutic Interfering Particles (‘ ...

Development of air vehicles capable of routine operation and able to achieve hypersonic speeds is paced by the availability of a propulsion system. The vision is to combine improved off-the-shelf turbines for low-speed operation (M=0 to 2+) and dual-mode ramjet (DMSJ) engine technologies for high-speed operation (M=2+ to 5+), with both engines sharing a common air inlet and a common thrust produci ...

During the phase I effort, Semandex Networks and its team designed and implemented a proof-of-concept cloud-based application for knowledge navigation and document discovery that combines powerful text analytics with an intuitive UI. The prototype capability is poised to transform current data archival systems into meaningful connected information. The proof-of-concept prototype developed during t ...

We propose to continue our project generating transgenic insect with improved nutrition for humans and livestock, building on the milestones we have reached and will continue to develop in phase I. We have already demonstrated insertion of exogenous reporter DNA into the insect, and continue to develop genetic engineering tools and techniques. We have expressed the biosynthetic pathway of interest ...

Despite over 100 years of research, decompression sickness (DCS) remains the mission-limiting factor in the design and execution of combat diving operations.Divers may spend over an hour decompressing after spending as little as ten minutes at the target depth.While decompressing, divers are limited in vertical mobility, making then susceptible to detection and threatening their survivability.This ...

Unlike conventional computers, the embedded computers found in vehicles, routers and other Internet of Things devices lack the capability to have their software remotely updated. Vulnerabilities discovered in such devices remain unpatched, creating a large and growing attack surface. We propose to address this limitation in our Identification and Modification of Features in Embedded Devices (IMFED ...

Typically, the electro-optical Mach-Zehnder interferometric intensity modulator is the key optical component that determines the ultimate performance of an externally-modulated high-performance analog RF fiber-optic link. Intrinsically, the device has a symmetric structure and has a transmission peak at zero bias. In order to operate at the maximum linearity quadrature point, the optical symmetr ...

In this Phase 2 program, nLight intends to demonstrate high-reliability / high-efficiency 808-nm broad area diode lasers. The root-cause of the failure modes of diode lasers investigated under Phase 1 will be addressed in this program. Collaborative work on built-in filament control by etching holes will continue in this program. Prototype designs first demonstrated by focused ion beam processi ...

In Phase I of this effort we analyzed the structural response of a BLU 109 during typical penetration events. Based on these finite element results, we proposed and demsonstrated a simple robust concept for a passive penetrator sensor that identifies the material being penetrated and also correlates strongly with its underground trajectory. Such a sensor would obviously provide valuable informatio ...

Orora Design Technologies proposes to develop electronic design automation (EDA) tools employing minimally invasive circuit design-based methods to mitigate single event effects (SEEs) for next generation Ultra-DSM CMOS (