Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Novel Methodology for Identification of Senolytics that Reduce Age-related Disease and Dysfunction

    SBC: Recursion Pharmaceuticals, LLC            Topic: NIA

    DESCRIPTIONprovided by applicantChronic diseases of aging account for a significant proportion of healthcare spending and result in a painful and limiting existence for many tens of millions of Americans and hundreds of millions of people around the worldRecursion Pharmaceuticals has developed a drug discovery platform that re purposes known drugs for the treatment of such diseasesThe platform con ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. High-throughput nanoMEA-based Proarrhythmia Assay

    SBC: CURI BIO, INC.            Topic: NHLBI

    PROJECT SUMMARY Failure of new drugs at late stages of development is an extremely costly event commonly associated with the detection of unexpected arrhythmogenic properties in novel drugs Undetected arrhythmia inducing effects are also a common reason for drug withdrawal from the market As a result the FDA now mandates that all new drugs be tested for potential arrhythmogenic properties which ha ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. STEM Interactive Digital Tool to Educate and Promote Hearing Health and Science for 4th to 7th Grade

    SBC: CREARE LLC            Topic: 500

    PROJECT SUMMARY ABSTRACT The National Research Council recognizes that serious computer games can support new inquiry based approaches to science instructionproviding virtual laboratories or field learning experiences that overcome practical and logistical constraints to student investigationsWith the nationally recognized need to encourage and enhance education in the ScienceTechnologyEngineering ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Interstitial Intensity Modulated Photodynamic Therapy Phase II

    SBC: SIMPHOTEK, INC.            Topic: NCI

    Photodynamic therapyPDTis a cancer treatment that utilizes visible or near infrared light to activate a lightsensitive drugphotosensitizerPSthatin turncreates reactive singlet oxygen species from ground triplet state oxygen that is present in the tumorThe resulting reactive products induce tissue deathIdeally the reactive species will be produced within only the target volumeleading to damage of t ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Complex 3-Dimensional in vitro Human Skin Tissue Models for Scleroderma

    SBC: CELDARA MEDICAL, LLC            Topic: NIAMS

    PROJECT SUMMARY Sclerodermasystemic sclerosisSScis an autoimmune disease of unknown etiology that is characterized by vascular dysfunctionfibrosisand inflammationOne in three patients dies withinyears of diagnosisgiving SSc the highest case fatality rate of any systemic autoimmune diseaseA lack of biologically relevant SSc disease models has created a critical unmet need for more efficient preclin ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing

    SBC: Twinstrand Biosciences, Inc.            Topic: 102

    TBD

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Adaptable Pediatric Neurocognitive Assessment

    SBC: CREARE LLC            Topic: 103

    PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Sleeping Beauty Engineered B Cells for Mucopolysaccharidosis

    SBC: Immusoft Corporation            Topic: 300

    Project Summary Mucopolysaccharidosis type IMPS Iis an autosomal recessive storage disease caused by the absence ofL iduronidaseIDUAresulting in systemic accumulation of glycosaminoglycanGAGstorage materialshepatosplenomegalyskeletal dysplasiascardiopulmonary obstructionprogressive neurologic impairment and death by ageMPS I is currently treated by enzyme replacement therapy and by allogeneic hema ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Optimization of an innate immune stimulating adjuvant for an HIV DNA vaccine

    SBC: Orlance, Inc.            Topic: NIAID

    Abstract There is a growing consensus that protection against HIV infection will require BOTH antiviral antibody responses as well as polyfunctional CDand CDT cells with potent lytic activityTo stimulate the breadthpotencyand rate of response requiredProfectus Biosciences intends to utilize its platform technologies based on DNA vaccines combined with genetic adjuvantsAs a step in that directiona ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. pRBC Contaminant Removal with Hemocompatible Porous Polymer Beads

    SBC: CytoSorbents Medical Inc.            Topic: NHLBI

    Packed red blood cellpRBCtransfusions save livesHoweverhundreds of thousands of non hemolytic transfusion reactions occur each year worldwideranging from mild fever and pruritisto serious lifethreatening reactions such as severe hyperkalemiaanaphylaxisand transfusion related acute lung injuryTRALIMild moderate reactions drive patient discomfortdocumentationand testing costs while serious reactions ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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