Award Data

We have developed a device to control intracranial hemorrhage without a craniotomy.The device stops hemorrhage transcranially.This has been demonstrated in pig cadavers.We have developed a functional prototype and intend to improve and test the device on human cadavers and in vivo in pigs.By the end of the proposed work, we expect to be prepared to submit IDE paperwork with the FDA and engage inve ...

This Phase 2 SBIR program will result in a commercializable and clinically tested Prosthetic Smart Auto-Alignment Tool (ProSAT), which addresses the need to facilitate rapid, accurate, quantitative, and systematic diagnosis and adjustment of the physical alignment of a prosthesis. ProSAT is a novel approach to alignment challenges by creating a hybrid sensor and smart tool system that can adjust e ...

Current strategies for the treatment of osteochondral injuries are ineffective and are associated with significant side effects. Microfracture techniques have demonstrated limited efficacy over long periods of time and are less effective for larger osteochondral defects. Osteochondral autograft transplants require harvesting from a donor site, which can lead to donor site morbidity. Further, while ...

Blast induced Traumatic Brain Injury (TBI) is a major threat to the health of military personnel serving in modern theaters. As such, the biomechanical injury pathways of TBI are, and have been, the focus of many animal studies. However, differences in the experimental setups across laboratories make it difficult to draw definitive conclusions from the resulting data. A tool that can accurately es ...

Traumatic brain injury is a common problem in both the military and civilian communities, but current treatment protocols are focused on managing symptoms and fail to prevent significant long-term repercussions. In the proposed program, Luna will demonstrate the feasibility of a liposome-based therapeutic delivery system capable of delivering hydrophilic and hydrophobic therapeutics to the traumat ...

The nature of military operations leads to high noise levels, exposing personnel to the possibility of noise induced hearing loss (NIHL). Individual hearing monitoring is conducted yearly which can only provide a record of the progression of irreversible hearing loss with limited options for intervention and mitigation. Furthermore, there is limited data that links actual, real-world noise exposur ...

Hearing loss is the third most common chronic physical condition in the U.S.more prevalent than diabetes or cancer. Globally, in 2015, about one half billion people had disabling hearing loss, or roughly 6 to 8% of the world population. Occupational hearing loss is one of the most common work-related illnesses and the most common service-related disability among veterans. As a result, more individ ...

The Defense Threat Reduction Agency (DTRA) recognizes the need for low-power high-bandwidth radiation-hard optical interconnects to process more data more quickly and to replace electronic data.Our companys core development in optical communications with semiconductor materials is a unique fit for DTRAs low-power consumption high-bandwidth radiation-hard intra-chip communication components for sat ...

Echo Ridge proposes to deliver a Hardware-in-the-Loop RF environment emulator with high fidelity scintillation simulation within which propagation models will in real-time accurately simulate a nuclear-disturbed environment for testing MILSATCOM communications links. The emulator will accommodate the attachment of physical devices (MILSATCOM communications link equipment or simulators), and/or mod ...

Drug dosingcan bemademore precise by using pharmacokineticand pharmacodynamicmodeling. Pharmacokinetics is thestudy of the concentration of drugs in tissueasafunction of timeand doseschedule,whereas pharmacodynamics is thestudy of therelationship between drugconcentration and drugeffect. By relating doseto resultant drugconcentration (pharmacokinetics)and concentration to effect (pharmacodynamics) ...