Award Data

Location FOCALCOOL, LLC 25 LYNNFIELD DR EAST WINDSOR, NJ 08520 United States 2R44HL088789-02A1 $939 644.00 2 008 A cooling guide catheter for rapid heart cooling Department of Health and Human Services National Institutes of Health SBIR N N N PHS2007-2 FO ...

PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

Prostate cancer disproportionally impacts African American men This project creates a cohort of metastatic prostate cancer patient derived xenografts PDX models for the express purpose of supporting efforts to elucidate clinical and molecular differences in prostate cancer between ethnic groups A cohort of up to metastatic prostate xenograft models will be generated using patient tissues an ...

This proposal describes enhancements to the ADEpT GIS, an internet-based software application that allows users to generate statistical analyses, maps, and reports on community-level measures of substance abuse. This web service augments the work of groups like the NIDA-sponsored Community Epidemiological Workgroups by providing a data repository and accessible analysis system for reporting and su ...

DESCRIPTION (provided by applicant): This goal of this SBIR project is to quantify and validate the feasibility and potential for a non- obtrusive, wearable, in-shoe gait-monitoring device for children with Cerebral Palsy (CP). It is hypothesized that continuous monitoring and analysis of simple gait parameters in children with CP outside the clinical laboratory and during normal daily activities ...

DESCRIPTIONprovided by applicantCardiovascular diseases and Asthma affects betweenandmillion people in the United States includingmillion childrenduring the pastyearsits incidence worldwide has doubledAsthma is responsible formillion person days of restricted activity anddeaths per yearamounting to $billion in direct heath related coststhere is uncertainty about the specific factors that are contr ...

Several types of cancerse gpancreatic and brain malignanciesremain extremely lethal despite the introduction of chemotherapy more thanyears agoThe hallmark of all cancers are somatic mutations which cannot be correctedIn sharp contrastepigenetic changesessential contributors to tumorigenesisare pharmacologically reversibleThe ability to remedy detrimental epigenetic alterations are opening up new ...

DESCRIPTION (provided by applicant): The goal of this work is to develop an antibody-doxorubicin conjugate for the targeted therapy of B-cell cancers that express the CD74 antigen. The Phase II project will focus on advancing this product for multiple myel oma, a common plasma cell malignancy that is incurable at this time. The average 5-year survival rate for these patients is only 30%, and there ...

Motor development plays a pivotal role in an infant’s overall development and has a cascading effect on social, cognitive, memory, and language ability. These functions can be compromised when motor development is disrupted; motor disruption is associated with generalized developmental delays. Early screening and identification of delays can allow early interventions with the goal of not just im ...

DESCRIPTIONprovided by applicantMicroarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugsTypicallyprotein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another deviceDuring each testing cyclethe entire microarray becomes exposed to the pro ...