Award Data

PROJECT SUMMARY ABSTRACT Opioid use disorder is the leading cause of accidental death in the USwith overlethal drug overdoses inSAMHSA estimates thatmillion Americans misuse prescription opioids for non medical purposes annuallyPublic health officials and policymakers have acknowledged the urgent need for innovative approaches to the treatment of those with opioid use disorderin spite of thisthe a ...

ABSTRACT Osteoporosis directly affectsmillion Americans and anothermillion are osteopenic and at risk for developing osteoporosisPostmenopausal osteoporosis is most commonbut osteoporosis does also frequently affect older menAt MAX BioPharmawe are developing new and improved therapies for osteoporosis that aim to rebalance both bone formation and resorption based on a dual therapy approachBisphosp ...

Project Summary Abstract Alzheimerandapos s diseaseADis a devastating neurodegenerative disease that affects more thanmillion peopleincludingmillion Americansworldwideand this number is expected to reach more thanmillion by the yearRecent disappointing results from a large number of clinical trials for AD treatment further aggravate the problemOne major challenge is there is currently no blood bas ...

AbstractThe primary goal of this study is to develop an automated scoring system of leptomeningeal collaterals based on CT angiographyCTAas a quantitative assessment of acute ischemic strokeLeptomeningeal collaterals provide an alternate path of blood flow in the setting of a proximal vessel occlusionThe presence and effectiveness of leptomeningeal collateralsi ecollateral statusvaries significant ...

7. PROJECT SUMMARY Neuropathic pain remains a poorly managed medical condition affecting more than 1.5 billion people worldwide. Over 20 million people suffered from diabetic neuropathy and neuropathic pain in the US alone in 2015. The current standard of care is insufficient. Topical applications and systemic treatment with existing analgesics, including opioids, leave millions suffering. More th ...

TITLETau oligomer platform validation using lead series candidate in htau mice PROJECT SUMMARYSBIR Funding OpportunityAdvancing Research on Alzheimerandapos s DiseaseADand Alzheimerandapos s Disease Related DementiasADRDRRPASThe long term goal of this program is to develop a disease modifyingsmall molecule drug for Alzheimer s diseaseADand related tauopathiesThere is a critical unmet need for a di ...

AbstractBrain swelling is a serious complication of traumatic brain injuryTBIischemic stroke and other serious conditionsTBI and stroke afflictM andK persons per year in the US aloneThey are a costly health care burden and a devastating social burdenCurrent treatments for brain swelling are limited and generally ineffectivehighlighting the dramatic unmet need for better therapeuticsA better unders ...

Project Summary Visionize has developed a sophisticated wearable state of the art low vision aid by reprogramming a readily available low cost off the shelf Virtual Reality systemThe device operates in three main modesThe patient views the real world with adjustable magnification power and area within the overall sceneThe patient also has access to the full complement of digital media ranging from ...

Project SummaryThe main cause of behavioral symptoms in patients with Alzheimerandapos s diseaseADis the deterioration of brain cells which causes a decline in the individualandapos s ability to make sense of the worldCoping with such difficult behaviors is challenging for many caregiversand it is associated with many distressful situationsDespite current knowledge of adverse effects of dementia o ...

Project Summary Sanfilippo disease (mucopolysaccharidosis type III; MPS III) is a devastating neurodegenerative lysosomal storage disorder of childhood whose pathologic features are neurologic: slowing of development, severe behavioral problems, progressive cognitive decline, dementia, and decline in motor skills leading to immobility, unresponsiveness, and death. We have focused on MPS IIID cause ...