Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Development/Commercialization of a Sensing Device to Detect Vaping

    SBC: FreshAir Sensor, LLC            Topic: NIDA

    Development Commercialization of a Sensing Device to Detect Vaping Summary The use of e cigarettes or vaping has been steadily increasing since its introductionWhile potentially a tool to wean cigarette smokers from combustible tobaccoone consequence of the introduction of these devices has been the adoption of vaping by adolescentsWhile companies that offer vaping instruments for sale note that t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Micronized salsalate in a parenteral formulation is a safe and effective analgesic for acute postoperative pain management

    SBC: RH NANOPHARMACEUTICALS L.L.C.            Topic: 102

    SUMMARYThe White House has initiated an aggressive campaign to combat the current opioid crisis that is affecting all levels of the American way of lifeThe opioid crisis has emerged from multiple frontsAmong these various frontsthe continued use of opioids in the post operative area is a growing addiction riskCurrent postoperative pain management utilizes a multimodal pain management strategywhich ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Long-term therapeutic effects of synthetic bryostatin-1 in advanced AD without memantine

    SBC: Neurotrope Bioscience, Inc.            Topic: R

    Program Director Principal InvestigatorLastFirstMiddleMiao Kun Sun Project Summary Abstract The importance of memory impairment and dementiasincluding Alzheimer s diseaseADas a global priority has been well recognizedMany compounds that target AD pathologies have been developed preclinically but have failed in clinical trialsmostly for the lack of therapeutic efficaciesNeurotrope Bioscience Incis ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Rapid and Effective Localized Neurovascular Cooling Using the Khione Insulative Catheter

    SBC: Tom L Merrill            Topic: 101

    Project Summary Stroke is theth leading cause of death and number one cause of adult disability in the United StatesThe primary goal of acute ischemic strokeAIStreatment is quickly restoring blood perfusionHoweverstudies have shown that this return of blood flowwhile necessarycan also cause damage to local tissue leading to poor patient outcomesTherapeutic hypothermiaTHhas been shown to be a robus ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Transforming smartphones into active sonar systems to detect opioid overdose

    SBC: Sound Life Sciences, Inc.            Topic: NIDA

    PROJECT SUMMARY ABSTRACT Opioid use disorderOUDand mortality from opioid overdose are significant public health concernsDeaths from opioid overdose are highly preventable with early detection and administration of naloxoneA key challenge of the epidemic is that overdose victims often die because they are alone or among untrained or impaired bystanders and thus do not receive timely resuscitationTh ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Organ-on-chip based assays for personalized assessment of renal resilience in aging patients

    SBC: Nortis, Inc.            Topic: NIA

    Project Summary Age related kidney diseasesincluding chronic kidney diseaseCKDand acute kidney injuryAKIare major health problems and an economic burden worldwideIn the U Salonemillion people are affected by CKD diseasealthough the vast majority of these individuals are unaware of their conditionA coexisting diseasea new medicationor a surgical procedure can overstress the already compromised kidn ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Screen molecules modulating MOR trafficking with a newly developed MOR/14-3-3 bioassay.

    SBC: BIOINVENU CORPORATION            Topic: NIDA

    Specific AimValidate the MORLinkLight assay with a pilot HTS to identify molecules modulating MOR traffickingSignificanceThe current crisis of opioid use disordersOUDsand opioid overdose deaths in the United States urgently demands safer and better therapeuticsTo develop better and safer therapeutic agents for the treatment of OUDsfirst and foremost is to have new bioassays which are different fro ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Connected Pharmacy Platform to Improve Adherence to Buprenorphine-Naloxone Prescription Treatment of Opioid Use Disorder

    SBC: Pillsy Inc.            Topic: NIDA

    Project Summary Abstract The United States is in the midst of an opioid epidemicInmost recent estimatesmillion people met diagnostic criteria for opioid use disorderOUDIn that same yearAmericans died of opioid overdose an average ofpreventable deaths per dayOpioid agonist therapyOATsuch as buprenorphine naloxoneBUP NALcan reduce opioid overdose deaths by at leastdecrease opioid misuseand improve q ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Direct Reprogramming of Human Fibroblasts into Functional Cardiomyocytes by Non-Integrating Cardiogenic Nanoparticles

    SBC: Tateva Therapeutics Inc.            Topic: NHLBI

    Abstract Generation of human pluripotent stem cells upon reprogramming of patient specific somatic cells and subsequent differentiation of the stem cells into more specialized cell types opened new exciting opportunities for human regenerative medicineDirect reprogramming of fibroblasts to various cell types including neural cells and cardiomyocytes using different sets of bioactive factors was su ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Targeted lympho-ablation as an alternative to HSCT to cure T1D

    SBC: AVM Biotechnology LLC            Topic: 200

    With insulin being the only approved treatment of Typediabetes mellitusT DMthere is a very large unmet medical need for a definitive cure for pediatric and adult patientsIncrease in obesityunhealthy dietand physical inactivity are driving the prevalence of diabetes among all agesIn the U Sdiabetes currently affectsof the population of all agesand it is the seventh leading cause of deathwith an est ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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