Award Data

Polyfluoroalkyl and perfluoroalkyl compounds (PFCs) have been used commercially since the 1940’s due to their high level of chemical stability, almost frictionless surface or waterproofing characteristics. Elevated levels of PFCs have been linked to cancer and other health problems including reproductive and developmental risks. PFOA and PFOS are amongst the most prevalent of the PFCs with low l ...

PROJECT SUMMARYCreare and its clinical and research partners propose to develop a software platformOnTRACKOnline Treatment Recovery Assistance for Concussion in Kidsfor children and adolescents recovering from concussion or mild traumatic brain injurymTBIThe platform includes a mobile applicationappfor the patients and their care teamparentsteacherscoachesetca database serverand a decision support ...

PROJECT SUMMARYABSTRACT Skeletal muscle atrophy diminishes the health and quality of life of tens of millions of people in the US aloneFrequent causes of muscle atrophywhich often co exist in the same patientinclude agingmalnutritionmuscle disusecritical illnesscertain medicationsand a broad range of chronic illnesses including cancerheart failureCOPDdiabetesrenal failurecirrhosisrheumatoid arthri ...

Pathological hallmarks of Alzheimerandapos s diseaseADinclude extracellular deposits of Apeptidesintraneuronal aggregates of abnormally phosphorylated tau protein and neuroinflammationMost proposed AD disease modifying therapies have focused on strategies that reduce brain Aamyloid or tau pathological accumulationHoweversuch approaches have been unsuccessful in late stage AD clinical trials and ma ...

Aging Frailty is a biologically driven geriatric syndrome of multisystem physiological decline that is distinct from normal aging and disproportionately increases vulnerability to adverse clinical outcomesFrailty has an overall prevalence ofof thoseyears and olderand there is growing awareness in the geriatric community to diagnose and treat this conditionas it is not an inevitable consequence of ...

Increased competition and improved lead times are desired by the Defense Logistics Agency (DLA) for the MILSTAR system battery assembly. Mainstream Engineerings unique integration of engineering, manufacturing, quality control, and integrated logistics support (ILS) provides the government with the best value for the proposed NSN.The MILSTAR nickel-metal hydride battery pack lacks sufficient comme ...

Mentis Sciences Inc. (Mentis) proposes to develop a refurbishment program that is capable of disassembling, inspecting, and re-building complex systems and components, with the initial system of focus being the Minuteman Missile Antenna/Antenna Pedestal Assembly.To become a refurbishment supplier, Mentis will develop and adapt inhouse processes for performing refurbishment services by leveraging c ...

Diode-Pumped Alkali Lasers (DPALs) have great potential for high-energy lasers. Proper design of these systems is challenging because many interrelated processes impact their performance, and critical kinetic rate coefficients are not well known. In response, our team is developing a comprehensive physics-based analysis/design tool, and experimentally determining key kinetic rate coefficients. The ...

This proposal seeks NDI Engineering Company (CAGE code: 4X596) to become approved as apotential source of supply to DLA for the MK 2 Nose Gear Launch Shaft Assembly, NAVAIRpart number 511224-1; Shaft, Shouldered, NSN 3040-00-224-9019. In Phase I, NDIEngineering Company submitted one a Source Approval Request (SAR) for the manufacturingof the Shaft Assembly defined as NAVAIR part number 511224-1. I ...

Fiber optic data links are attractive for their wide bandwidth, low weight, electromagnetic interference immunity and ability to transmit high fidelity analog and digital radio-frequency-over-fiber (RFoF) signals. Multicore fiber (MCF) links will provide even higher capacity and density and enhance dynamic range analog links using parallel fibers of precisely equal length. The need for a high-qual ...