Award Data

ABSTRACT Early detection of mentalemotionaland behavioral disorders is vital to prevent ongoing impairment and provide effective treatment servicesPediatricians report the need for standardizedeasily deployedaccessibleand automatically scored mobile screening measures for completion by parents in waiting rooms prior to commencing office visits in pediatric primary care settingsConsistent use of de ...

Project Summary Abstract Confusionbeing lostand losing track of oneandapos s orientation within large or unfamiliar indoor spacesthese are some of the biggest challenges facing people with visual disabilitiesSince GPS typically doesnandapos t work indoorsand isnandapos t fine grained enough anywayindividuals who cannot readily access visual information are at a significant disadvantageand many bli ...

An estimated 10,000 animals are used in toxicology safety assessments to meet all regulatory requirements with testing spanning 5 to 10 yrs and exceeding $10 million dollars. There is a critical need to reduce reliance on animal testing and to develop highly predictive human-based biological models for safety assessments. Replacement of traditional animal toxicity tests for toxicology safety asses ...

Project SummaryA significant cause of mobility impairment in the elderly is peripheral arterial diseasePADPAD results in significant functional declinereduced walking speed and distanceand lower physical activity levelsresulting in a loss of independence and impaired quality of lifeThe most effective therapy for PAD is rigorous exercisee gwalkingHowevermost PAD patients will not participate in sup ...

ABSTRACT Intracerebral hemorrhageICHis a devastating form of cerebrovascular disease with no FDAapproved treatmentsIt is generally accepted that ICH induced neuroinflammatory responses mediate development of cerebral edemaintracranial hypertensionand secondary neuronal injuryOne promising strategy for ICH neuroinflammatory modulation is through the downstream effects of apolipoprotein EapoEPreviou ...

Dry eye diseaseDEDaffects visual function and quality of lifeand it is estimated to be prevalent inof adults agedyears old or older worldwide with females representing two thirds of this populationMeibomian glandMGdysfunction is age related and is the leading cause of DEDMuch of what is known about the agerelated changes in MGs has been derived from clinical studies performed in patients that meas ...

ABSTRACT Acute kidney injuryAKIis commonexpensive to treatand associated with andgtmortalityEach yearmillions of patients undergo cardiovascular surgerymedical imagingor cytotoxic chemotherapyall of which place them at significant risk for AKIAroundof cardiac surgery patients develop AKIwith even mild AKI significantly increasing the risk of negative outcomes such as progression to chronic kidney ...

PROJECT SUMMARYCreare and its clinical and research partners propose to develop a software platformOnTRACKOnline Treatment Recovery Assistance for Concussion in Kidsfor children and adolescents recovering from concussion or mild traumatic brain injurymTBIThe platform includes a mobile applicationappfor the patients and their care teamparentsteacherscoachesetca database serverand a decision support ...

Project Summary The Diagnostic Interview Schedule for ChildrenDISChas served as a gold standard assessment for diagnosing DSM disorders in children and has been cited in overpeer reviewed publicationsInthe DSM IV TR was updated to DSMWhile a gold standard instrumentthe DISCis also cumbersomeit is apage document with overtext pieces and a complex branching patternAn electronic versionthe cDISC was ...

Mentis Sciences Inc. (Mentis) proposes to develop a refurbishment program that is capable of disassembling, inspecting, and re-building complex systems and components, with the initial system of focus being the Minuteman Missile Antenna/Antenna Pedestal Assembly.To become a refurbishment supplier, Mentis will develop and adapt inhouse processes for performing refurbishment services by leveraging c ...