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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. GreenCare Interactive Guide for Knee Replacement Surgery

    SBC: PEER Technologies PLLC            Topic: NIA

    Project SummaryAbstract The goal of this Phase I work is to finish development of an innovative interactive app designed to help patients appropriately use total knee replacementTKRsurgery and provide support to achieve best outcomesTKR is highly effective for treating advanced osteoarthritis of the kneebut it has risksAppropriate use can be assured by engaging patients in a Shared Decision Making ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Adaptable Pediatric Neurocognitive Assessment

    SBC: CREARE LLC            Topic: 103

    PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Development of CM-SV1, a monoclonal antibody treatment for Sudan Virus

    SBC: CELDARA MEDICAL, LLC            Topic: NIAID

    PROJECT SUMMARY The filovirusesfamily Filoviridaecomprising five ebolavirusesa cuevavirusand two Marburg virusesare negative strand RNA viruses that cause severe hemorrhagic fever with up tohuman case fatality rateTheepidemic in Western Africacaused by the Zaire ebolavirusEBOVspecies demonstrated the potential for these viruses to cause dire health emergencies of global scopeand highlighted the ne ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Targeting leukocyte metabolism to treat human autoimmune disease

    SBC: Immunext, Inc.            Topic: R

    ImmuNext has defined an anti MCTmonoclonal antibodymAbthat will be developed for the treatment of human autoimmune diseaseThe membrane monocarboxylate nutrient transporter SLCAMCTis a multi pass transmembrane protein responsible for the facilitated transport of critical metabolitesincluding products of glycolysislactatepyruvate and ketonesOur strong preliminary data support the tenet that mAbs tha ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Smart Cavity Creator Drill for Lumbar Interbody Fusion

    SBC: PEER Technologies PLLC            Topic: NIBIB

    PROJECT SUMMARYABSTRACT Older patients with persistent and progressive symptoms of chronic back pain and leg pain often have a diagnosis of lumbar degenerative spondyolisthesis and undergo complex lumbar decompression and fusion surgeryOverof these procedures are performed in the United States each yearSurgery is highly effective but technically challengingOne technical challenge of fusion in spon ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Specificity and safety of a targeted therapy against triple negative breast cancer

    SBC: CELDARA MEDICAL, LLC            Topic: 102

    PROJECT SUMMARY ABSTRACT Despite recent advances in the treatment of breast cancerBCthere is a pressing unmet medical need as BC remains the second leading cause of cancer related deaths among womenInnovative new approaches are especially needed to help patients with triple negative BCTNBCas TNBCandapos s inherently aggressive clinical behavior and the lack of recognized molecular targets for ther ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Nanoparticle Probes to Objectively Measure Pain Following Back Surgery

    SBC: PEER Technologies PLLC            Topic: NIDA

    AbstractPost operative pain is poorly managed and increases risk for delayed recoverychronic painopioid dependenceand persistent disabilityOne barrier to effective management of acute pain is the absence of objective measuresWe propose to conduct a feasibility study for technology to objectively measure postoperative painWe have selected back surgery as a model given its frequencycostand poor outc ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Socializing a Science-based Digital Therapeutic for Substance Use Disorders

    SBC: Square2 Systems, Inc.            Topic: NIDA

    Digital therapeutics are redefining the future of medicineDigital therapeutics refer to the use of mobile technology to provide personalizeddigital health interventions to treat diseasesThese tools enable anytime and anywhere healthcareGiven that there are more mobile phones in the world than there are people in the worlddigital therapeutics offer the potential to be transformativeThe applicant te ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. A Smart Sensing Drill to Reduce Incidence of Dental Implant Complications

    SBC: RYTEK MEDICAL, INC.            Topic: NIDCR

    PROJECT SUMMARY ABSTRACT Clinical ImportanceAlmostmillion dental implants were placed worldwide inwithmillion of these procedures taking place in the United StatesThe worldwide market for these implants is expected to increase to $$billion in revenue byas more patients opt for this procedure to regain chewing function and improve cosmetic appearanceThe procedure itself requires an osteotomy be dri ...

    STTR Phase I 2018 Department of Health and Human Services
  10. A Non-Contact Optical Patient and Beam Dosimetry System for Continuous in vivo Radiotherapy Verification

    SBC: DoseOptics LLC            Topic: 102

    Abstract Optical Cherenkov video imaging of body anatomy and dose delivery can be used now to map out radiotherapy beam incidence upon the patient tissuedirectly visualizing the radiation dose deposition on the patient in real timeThis could serve as a non contact workflow tool for verification for daily fractionated radiation therapyallowing capture of all treatmentsall the timeDoseOptics has dev ...

    SBIR Phase I 2018 Department of Health and Human Services

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