Award Data

Abstract Type A and B Influenza viruses cause severe seasonal epidemics and less frequent but more deadly pandemic infectionsVaccination provides the best protectionalthough serious problems are confronting the global Influenza marketVirus diversity and mutation rates necessitate the annual production of hundreds of millions of vaccines using antiquated egg based technologiesCompounding this is th ...

Project SummaryWe propose in this SBIR effort to develop a mobile platform basedlow costyet highly accurateD scanner for audiologists or dispensers to quickly capture ear structure and locally optimize custom fit hearing aid shell design through rapid prototypingHearing loss is the third most prevalent chronic health condition facing seniorsUntreated hearing loss has been shown to lead to physical ...

Project Summary SignificanceSinceavian influenza AH Nhas sickened overpeople with amortality rateHalf of all cases occurred inwhich also saw the emergence of a highly pathogenic strainThusH Navian influenza is poised to emerge as a devastating pandemic in a worldwide population that has no pre existing immunityCurrent Hvaccineswhether attenuatedinactivatedsplit or recombinantare insufficiently imm ...

Project Summary AbstractAlzheimerandapos s DiseaseADaffects millions of Americansyet there are no treatments that meaningfully affect disease progression once symptoms manifestThis has shifted the focus to early detection and interventionwhich is thought by many researchers to offer the best chance of slowing or stopping the progression of ADHowevertrials aimed at averting the underlying causes of ...

PROJECT SUMMARY ABSTRACT SignificanceThe Knee Biofeedback Rehabilitation Interface for Game based Home TherapyKneeBRIGHTsystem combines electromyographyEMGbiofeedback with video game therapyVGTto provide knee osteoarthritisOApatients with an engagingeffective tool for conducting rehabilitation exercises at homeKneeBRIGHT aims to motivate patients with knee OA to conduct regular muscle strengthenin ...

Project Summary This project addresses a critical need for early detection of mild cognitive impairment (MCI) and other Alzheimer's-related dementias (ADRD). Advances in smartphone hardware, computer vision, and machine learning have enabled the possibility of producing smartphone-based cognitive testing applications able to collect electronic sensor data and transform it into highly informative ...

PROJECT SUMMARY Failure of new drugs at late stages of development is an extremely costly event commonly associated with the detection of unexpected arrhythmogenic properties in novel drugs Undetected arrhythmia inducing effects are also a common reason for drug withdrawal from the market As a result the FDA now mandates that all new drugs be tested for potential arrhythmogenic properties which ha ...

PROJECT ABSTRACT The proposed research builds on a successful Phase I SBIR grant to develop and test a web based version of a parenting after divorce group interventionthe New Beginnings Programwhich has been shown in two randomized trials to reduce youthsproblem behaviors and enhance their developmental competencies in theyear period after their parents participatedThe proposed web based format w ...

PROJECT SUMMARY Increased renal sympathetic activity is a causal pathogenetic mechanism of both cardiovascular hypertension and progressive loss of renal function in patients with chronic kidney diseaseCKDIn millions of patients with resistant hypertensiondependable thermal disruption of targeted renal sympathetic nerves can reduce blood pressure and ultimately prevent heart diseasestroke and kidn ...

Abstract Despite global success of interventional cardiac surgery for treatment of arrhythmias, electroanatomical mapping (EAM) of the heart has significant drawbacks. The procedure is slow and prone to registration errors, largely ineffective for treating transient arrhythmias, such as ventricular tachycardia, and exhibits relatively poor spatial resolution. With only a 50% success rate for first ...