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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Synthetic Universal Flu Vaccine

    SBC: TRIA BIOSCIENCE CORP.            Topic: NCIRD

    Abstract Type A and B Influenza viruses cause severe seasonal epidemics and less frequent but more deadly pandemic infectionsVaccination provides the best protectionalthough serious problems are confronting the global Influenza marketVirus diversity and mutation rates necessitate the annual production of hundreds of millions of vaccines using antiquated egg based technologiesCompounding this is th ...

    SBIR Phase I 2018 Department of Health and Human ServicesCenters for Disease Control and Prevention
  2. Engineering Nanoparticle Alum Adjuvants for Pandemic Influenza Vaccines

    SBC: HDT BIO CORP            Topic: NCIRD

    Project Summary SignificanceSinceavian influenza AH Nhas sickened overpeople with amortality rateHalf of all cases occurred inwhich also saw the emergence of a highly pathogenic strainThusH Navian influenza is poised to emerge as a devastating pandemic in a worldwide population that has no pre existing immunityCurrent Hvaccineswhether attenuatedinactivatedsplit or recombinantare insufficiently imm ...

    SBIR Phase I 2018 Department of Health and Human ServicesCenters for Disease Control and Prevention
  3. High-throughput nanoMEA-based Proarrhythmia Assay

    SBC: CURI BIO, INC.            Topic: NHLBI

    PROJECT SUMMARY Failure of new drugs at late stages of development is an extremely costly event commonly associated with the detection of unexpected arrhythmogenic properties in novel drugs Undetected arrhythmia inducing effects are also a common reason for drug withdrawal from the market As a result the FDA now mandates that all new drugs be tested for potential arrhythmogenic properties which ha ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Preparation and development of a stabilized C3 analog for the treatment of paroxysmal nocturnal hemoglobinemia

    SBC: Cascade Biotechnology            Topic: NHLBI

    Abstract We propose to develop analogs of human complement Cthat have the ability to form a stable CconvertaseIn additionthese proteins will be designed to decrease the affinity of the proteins for factor H bindingAll proteins will be expressed in the Baculovirus insect protein expression systemand tested for their ability to form a stable Cconvertase enzyme that is able to deplete complement in h ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Transforming STEM Education in K-12 using the Biological Interactive Outcomes Modular Environment (BIOME)

    SBC: IQ Smart Interactive LLC            Topic: 500

    PROJECT SUMMARYThe United States is falling behind in Science and Math according to results from the Programme for International Student AssessmentPISAranking the US asth in Science andth in Mathematics out ofcountriesThese unfortunate statistics could be attributed to teacher hesitations in teaching math and scienceinability to excite student interest in STEM subjectsor an unclear real world appl ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Interstitial Intensity Modulated Photodynamic Therapy Phase II

    SBC: SIMPHOTEK, INC.            Topic: 102

    Photodynamic therapy (PDT) is a cancer treatment that utilizes visible or near-infrared light to activate a light- sensitive drug (photosensitizer, PS) that, in turn, creates reactive singlet oxygen species from ground triplet state oxygen that is present in the tumor. The resulting reactive products induce tissue death. Ideally the reactive species will be produced within only the target volume, ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Development and Validation of a Platform to Assess and Improve Barriers to Health for Digitally Underserved Populations

    SBC: Responsive Health, Inc.            Topic: 102

    Project SummaryInflammatory bowel diseaseIBDis a chronic disabling disease that leads to poor quality of life among otherwise young healthy adultsUnderserved and minority populations bear a higher disease burden with more hospitalizations and less use of gastroenterology specialty care and of maintenance medications to prevent flaresThe goal of this proposalDevelopment and Validation of a Platform ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a PSMA-Targeted Small-Molecule Drug Conjugate for Prostate Cancer

    SBC: Cancer Targeted Technology LLC            Topic: 102

    PROJECT SUMMARY ABSTRACTProstate Specific Membrane AntigenPSMAis an andapos ideal biomarkerandaposfor tumor targeting as it exhibits restricted expression on prostate tumor cells and the neovasculature of a number of other solid tumorsCancer Targeted Technology has developed unique phosphoramidate based PSMA inhibitor scaffolds that irreversibly bind to the enzyme target and selectively penetrate ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. TrachAlarm: A novel, low-cost accessory to automatically detect and alert caregivers to tracheostomy tube decannulation

    SBC: INNOVATIONS UNLIMITED LLC            Topic: NINR

    ABSTRACT The objective of the Phasegrant is to designdevelopand demonstrate feasibility of TrachAlarma novellow cost accessory to automatically detect and alert caregivers when a tracheostomy tube has become accidentally removed from the patientTracheostomy provides a criticallife supporting function for overmillion individuals in the United States with overnew procedures performed each yearEach o ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing

    SBC: TWINSTRAND BIOSCIENCES INC            Topic: 102

    Nearly a quarter of a million new cases of ovarian cancer are identified every year worldwide and the majority of these woman will die from their disease. When detected early, surgical cure rates exceed 90%, but currently most cases are detected at an advanced stage when the cancer has already disseminated. As such, our most pressing problem in ovarian cancer is a lack of tools to identify early s ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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