Award Data

DESCRIPTION (provided by applicant): As a result of growing evidence of their therapeutic potential in cancer, infectious diseases, and tissue repair, there is an enormous increase in the research and discovery of cell-based medical treatments that require cultured cells. A large unmet need exists for a cost-effective system that will facilitate the development of clinical cell production capabil ...

DESCRIPTION (provided by the applicant): Dendritic cells have been shown to initiate, regulate, and direct cytolytic T-cell-mediated immune responses against tumor antigens in human patients. Recent clincal trials have demonstrated induction of clinically significant immune responses against malignant diseases using DCs primed ex vivo with autologous tumor antigens including tumor cell lysates. E ...

DESCRIPTION (provided by applicant): Adherent mesenchymal cell populations derived from bone marrow (BM) have the capability of differentiating into multiple cell lineages in vitro and in vivo. The potential use of these populations, referred to as marrow stromal cells (MSC), in clinical applications to treat nonhematopoietic disorders is being intensely investigated. Ex vivo expansion is being us ...

DESCRIPTION (provided by applicant): Due to morbidity and limited amounts of material, alternatives to autologous grafts for bone repair are desirable. Mixtures of marrow stromal cells (MSC) and carrier matrices are known to augment bone repair. Increasing the number of MSC through ex vivo expansion may significantly increase the amount and rate of new bone formation. In this proposal, the abilit ...

DESCRIPTION (provided by applicant): Treatment of ischemia by administration of bone marrow (BM)-derived endothelial progenitor cells (EPC) or ex vivo expanded EPC populations has been shown to enhance vascular regeneration in animal models and in clinical trials. For cell therapy to be practical in a clinical setting, simple, efficient, GMP compliant methods for cell production are needed. Aastro ...

This proposal seeks to demonstrate the feasibility of using impulse radar techniques to detect and identify explosive detonators. It relies on the fact that a radar impulse will excite natural electromagnetic resonances which characterize the size, shape, and material composition of an object. These resonances are present in the scattered transient return from the object and can be extracted by ...

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THREE TO FOUR MILLION YOUNG CHILDREN FROM ALL LEVELS OF SOCIETY ARE EXPOSED TO ENVIRONMENTAL SOURCES OF LEAD AT CONCENTRATIONS THAT PLACE THEM AT RISK FOR ADVERSE HEALTH EFFECTS. YET, THERE IS NO TOOL AVAILABLE FOR MEASURING TOTAL PEDIATRIC BODY BURDEN OF LEAD. THIS PROJECT WILL DEVELOP AN X-RAY FLUORESCENCE (XRF) INSTRUMENT THAT WILL ALLOW MEASUREMENT OF BODY LEAD BURDEN IN CHILDREN IN VIVO AND N ...

CENTRIFUGAL BLOOD PUMPS HAVE BEEN USED EXTENSIVELY FOR SHORT-TERM CIRCULATORY ASSISTANCE AND PERFUSION PUMPS. THEIR UTILITY FOR LONG-TERM VENTRICULAR ASSISTANCE IS LIMITED BY THROMBUS FORMATION AT THE SHAFT SEAL. ABIOMED, INC., WILL DEVELOP A MAGNETICALLY SUSPENDED CENTRIFUGAL BLOOD PUMP THAT WILL HAVE NO SHAFT SEAL AND BE SUITABLE FOR LONG-TERM CIRCULATORY SUPPORT IN EITHER AN IMPLANTED OR EXTRAC ...

THIS RESEARCH WILL DEMONSTRATE THAT A NEW 1.9-MU M LASER CAN PERFORM LASER-ASSISTED VASCULAR ANASTOMOSES OF SMALL-DIAMETER VESSELS (1 TO 5 MM). THE 1.9-MU M LIGHT HAS OPTIMAL ABSORPTION CHARACTERISTICS TO ENSURE AN EVEN DEPOSITION OF ENERGY IN THE VESSEL WALL. THIS SHOULD RESULTIN A MORE DESIRED TEMPERATURE PROFILE IN THE REGION OF THE ANASTOMOSIS WHEN COMPARED WITH ALTERNATIVE SOURCES. THE PROPOS ...