Award Data

NON-TECHNICAL SUMMARY: This is a phase I SBIR proposal by Adenosine Therapeutics for 6 months of support to synthesize and evaluate novel compounds as agonists of equine A2A adenosine receptors. Some of these compounds have been found to be very effective in reducing rodent mortality form endotoxin or from E. coli-induced sepsis. Circulating endotoxin (lipopolysaccharide) is correlated with the pr ...

This proposal describes an SBIR Phase II program to develop, optimize, and demonstrate the effectiveness of hybrid composite armor for AAAV. Hybrid composite armor systems, comprised of unique combinations of dissimilar composite materials, offer lightweight protection at a much lower cost than other high performance composites. Ballistic protection data and models for commercial composite armor ...

DESCRIPTION (provided by applicant): The ribonucleoprotein complex telomerase has been implicated in the establishment and progression of many different types of tumors. Telomerase activity is detected in roughly 80 percent of all tumor cell types, but is absent in most normal cells. Thus, the disruption of telomerase activity is a particularly attractive means for treating multiple types of cance ...

This innovation proposes the use of a thin film stratospheric balloon to lift a launch vehicle with a payload to an altitude above most of the Earth's atmosphere, then ignite the launch vehicle rocket motor. It will have the capability to carry the payload to its final destination, either into Earth orbit or to the mission design goal. This launch system will eliminate the first stage rocket thr ...

The objective of the Ballistic Missile Defense System (BMDS) is todetect, identify, and track targets using sensor observations, andengage the lethal objects using interceptors.To achieve the desired level of effectiveness, the system mustdistinguish between the lethal and non-lethal objects.Object identification is performed by a discrimination systemthat relies on a tracking system to associate ...

DESCRIPTION (provided by applicant): ABC transporters pump a variety of small molecules and peptides across cell membranes. Mutations in ABC transporter genes cause severe defects in man. Drugs that modulate ABC transporter function would have utility as anti-microbials through inhibition of essential microbial ABC transporters, as well as in the states of atherosclerosis, macular degeneration, di ...

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THE REQUIREMENTS OF SPACE WARFARE DICTATE THE NEED FOR INNOVATIVE TECHNOLOGIES TO SOLVE COMPLEX SPACE OBJECT CLASSIFICATION PROBLEMS. ADVANCES IN COMPUTING SPEED AND EXISTING SOFTWARE TECHNOLOGY ALONE ARE UNLIKELY TO RESULT IN A REAL-TIME DISCRIMINATION SYSTEMS CAPABLE OF MEETING THE COMPLEX REQUIREMENTS OF SPACE OBJECT SURVEILLANCE AND CLASSIFICATION. RATHER, AN ALTERNATIVE METHODOLOGY SUCH AS AB ...

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DESCRIPTION (provided by applicant): While density-functional calculations of the energy are now feasible for biomolecules, the use of density-functional geometry optimizers is still confined to relatively small molecules containing no more than thirty atoms. The key limitation of conventional density-functional geometry optimizers is that the cost of the geometry optimization scales at least qua ...