Award Data

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is to develop a disruptive technology that reduces the environmental impact of greenhouse-based agriculture while simultaneously improving its economic potential through the application of semitransparent organic solar cells onto the greenhouse glazing (i.e., windows). Greenhouses can be a form of hig ...

This Small Business Technology Transfer Phase I project will develop a completely new class of spectrometer, the spherical transmission grating spectrometer (STGS), which utilizes curved volume phase holographic (VPH) gratings coupled with a spherical mirror to deliver aberration-corrected spectral images over the full field of view. The market is projected to reach $35.8 billion by 2026, at an an ...

Developing regional marine renewable energy resource characterizations and assessments is a significant technical challenge which requires state-of-the-art modeling, application of best modeling practices, accurate model skills, high-quality inputs, and high-performance computing resources. Further, resource characterization and assessment for Powering the Blue Economy markets is needed, especiall ...

Bioprocess development, scaleup and optimization is a significant undertaking. A lack of complete understanding of the underlying biological processes and a shortage of a trained workforce in this field has made the development process slow and inefficient, thus leading to continued reliance on non-renewable petroleum-based chemistries for fuels and chemicals. The overall goal of this project is t ...

ABSTRACT The goal of this STTR proposal is to develop a novel anti-fibrotic agent suitable for oral administration which could be used to safely and effectively treat Systemic Sclerosis (SSc), or Systemic Scleroderma patients. SSc is one of the most disabling and lethal immune-mediated rheumatic disorders. SSc is a rare disease, affecting 40,000-150,000 people in the United States and conferring a ...

ABSTRACT Significant advances in the specific targeting of delivery vectors and the increased therapeutic efficacy of such vectors for gene delivery have been made, stimulating major interest in the development and commercialization of therapeutic products focused on gene therapy indications. CLAIRIgene LLC focused on the development and optimization of various viral gene-to-cell transfer delivery ...

PROJECT SUMMARY To achieve the FDA’s required Sterility Assurance Level for use in humans, pharmaceutical products must undergo terminal sterilization or aseptic manufacturing. This can be accomplished using physical or chemical methods such as heat or formaldehyde for simple drug formulations; however, for pharmaceutical products that have more complex drug formulations or that contain biologic ...

Abstract: A Therapeutic Role for Apolipoprotein-E in the Germ Theory of ADP. gingivalis is the keystone bacteria of periodontal disease, the 6th most common infectious disease worldwide. Half of all Americans over the age of 30 and 70% of those over age 65 suffer some degree of P. gingivalis infection associated with gum disease. In a study of 6800 patients with gum disease that were followed for ...

Adeno-associated virus (AAV) vectors have been successfully employed in patients with rare neurological diseases. Recently, two AAV based gene therapy drugs have been approved by the FDA, Luxturna been valued at $850,000 with a one-time application for blindness and Zolgensma at $2,100,000 for spinal muscle atrophy. AAV vector mediated gene therapy has shown to be a potentially huge market. Althou ...

PROJECT SUMMARY Diabetic Retinopathy (DR) is a serious diabetic complication that is the leading cause of vision loss in working- age adults, affecting more than 7.5 million people in the USA. It causes more new cases of blindness than any other eye disease in people between the ages of 18 and 65. The anti-VEGF treatments can slow the progress of DR in many patients but are only used after signifi ...