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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. MTI-301 a SCD1 inhibitor for the treatment of NASH

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 300

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in children and adults associated with diet-associated hepatic lipid accumulation (steatosis), and is a common hepatic manifestation of obesity and metabolic syndromes including diabetes. Modulation Therapeutics is developing a stearoyl- coenzyme A desaturase-1 (SCD1) inhibitor for the treatment of NAFLD a ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Developing a Digital Training and Assessment Platform to Disseminate a Successful NIH-Supported College Preparation Model for Diversifying the U.S. Biomedical Workforce

    SBC: MOTHER COMMUNICATIONS CO.            Topic: 500

    Abstract: Developing a Digital Training and Assessment Platform to Disseminate a Successful NIH- Supported College Preparation Model for Diversifying the U.S. Biomedical Workforce This Phase 1 SBIR project will design and test a digital training and assessment platform—HSTA Hatch—to help geographic regions outside West Virginia (WV) establish workforce development programs for grade 9-12 youth ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Modulation of cancer induced immune suppression via inhibition of SCD1

    SBC: MODULATION THERAPEUTICS, INC.            Topic: NCI

    PROJECT SUMMARY Metabolic reprogramming plays a critical role in carcinogenesis, in part due its ability to promote immunesuppressive properties within tumors. It remains unclear whether inhibition of fatty acid metabolism in tumorsaffects their immunogenicity. We show that inhibition of stearoyl CoA desaturase 1 (SCD1), the rate limitingenzyme involved in fatty-acid synthesis converting saturated ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Scaling Volumetric Imaging, Analysis and Science Communication Using Immersive Virtual Reality: Administrative Supplement

    SBC: ISTOSVISIO INC            Topic: 101

    The original Phase IIb proposal addressed problems in analyzing, accessing and communicating increasingly large 3D and 4D image sets in neuroscience. This supplement request is motivated by two unforeseen developments since submission and review of the original application. The requested activities are necessary to maintain the high overall impact of the project. First, due to larger than expected ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Mouse Home Cage Health Monitoring Using Virtual Cage Inspection and a Digital Health Biomarker

    SBC: WRIGHT WOLD SCIENTIFIC LLC            Topic: 100

    AbstractTens of millions of rodents are used for scientific research yearly. These animals are necessary for disease model testing and are essential for pre-clinical development of human therapeutics. Despite this great need, the current best practice for management of mouse colony health relies on manual checking, which is stressful for animals, time consuming and error-prone. While advances have ...

    SBIR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Improved Methods and Commercialization of Native Mass Spectrometry by Capillary Vibrating Sharp-edge Spray Ionization (cVSSI)

    SBC: Invibragen Inc.            Topic: 400

    Abstract/Summary Over the last 20 years, mass spectrometry (MS) instrumentation has advanced at a remarkable clip. Improvements in ion focusing, mass analyzer, and ion detection regions have greatly enabled the study of protein molecules in their native state (native MS). One area that has remained relatively constant is the ionization source where nanoelectrospray ionization (nESI) has remained t ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Prevention of arthritis-induced bone erosion by inhibiting osteoclast differentiation by the haloanilide, N-Methyl Dichloropropionaniline

    SBC: ExesaLibero Pharma            Topic: NIAMS

    We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and joints. Inflammatory arthritis disables thousands of people each year. It occurs in children and adults, after trauma and infections but most cases are idiopathic. Millions of adults live with chronic RA, which has similar features. Inflammatory arthritis often r ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Streamlining Volumetric Imaging, Analysis and Publication Using Immersive Virtual Reality

    SBC: ISTOSVISIO INC            Topic: 101

    Over the past 15 years, new imaging technologies and methods for high throughput imaging have revolutionized structural biology by extending the resolution and scale of collected images in 3 dimensions. The resulting image volumes are more typically hundreds of GB to even tens of TB and in some cases approach PB sizes. These file sizes pose challenges for image acquisition, image analysis, and com ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Prevention of arthritis-induced bone erosion by inhibiting osteoclast differentiation by the haloanilide, N-Methyl Dichloropropionaniline

    SBC: ExesaLibero Pharma            Topic: NIAMS

    We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and jointsInflammatory arthritis disables thousands of people each yearIt occurs in children and adultsafter trauma and infections but most cases are idiopathicMillions of adults live with chronic RAwhich has similar featuresInflammatory arthritis often requires trea ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Bioengineering a non-pathogenic bacteria to produce medically-relevant biopolymers

    SBC: Progenesis Technologies, LLC            Topic: 300

    Project Summary AbstractAlginate is a biopolymer with a wide array of applications infoodpersonal care products and biomedicineIn addition to its role as a tablet excipient and antacid treatmentalginates play an important role as a nonadherentexudate absorbing gelfor advanced wound care dressingsHistoricallyalginates for this application have been obtained from brown seaweedbut the problems with t ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
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