Award Data

One in three humans currently living on earth are infected with Mycobacterium tuberculosis, the bacterium that causes tuberculosis. This number is astonishing and underscores our ever-increasing need for accurate and efficient tuberculosis diagnostics. This is especially true for the US military wherein troops are serving in areas around the world that have high tuberculosis incidence rates. While ...

Tuberculosis (TB) is a re-emerging infectious disease threat worldwide. To protect the health of US military personnel, TB screen is required for military personnel at the time of service entrance. However, current TB screening methods TST and IGRA used in military population have their drawbacks in application such as high false positives and being heavily lab dependent. Here ADA Technologies, ...

The World Health Organization estimates that more than one-third of the worldwide population is infected with Mycobacterium tuberculosis (MTB), the causative agent of most cases of tuberculosis (TB). Patients who are infected with MTB, but do not have active TB disease have latent tuberculosis infection (LTBI), a non-communicable, asymptomatic condition which might develop into active TB disease m ...

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis (Mtb) that primarily affects the lungs. Approximately one third of the world"s population is latently infected with Mtb and at risk for developing active TB disease. Mtb grows slowly with visible growth appearing on solid media in 3 to 6 weeks. Automated broth systems requires a minimum of 9 days. Currently used rapid diagnostic a ...

This Small Business Innovation research Phase I proposes the development of a practical and reliable in-vitro test for detecting the evidence of Mycobacterium tuberculosis (MTB) infection as an alternative to the tuberculin skin test (PPD-TST) and to the interferon gamma release assays (IGRAs). The proposed methodology will be a powerful detection technology in clinical diagnosis owing to its dete ...

Tuberculosis (TB) is a significant disease worldwide, with 1.7M deaths and 10M new infections every year. From the Armed Forces"perspective, approximaely 3.5% of all new recruits have latent TB infection, 5-15% of whom may develop active disease in their lifetime. Armed Forces personnel are at particular risk of exposure to Mycobacterium tuberculosis (M.tb) given their deployments to endemic are ...

The objective of this proposal is to develop an alternative to the tuberculin test and interferron-gamma release assays for the diagnosis of active and latent tuberculosis. Toward this end, a rapid test based on the detection of blood antibodies specific to Mycobacteria tuberculosis antigens will be devised for the serodiagnosis of active and latent TB. Selected and highly immunogenic antigens enc ...

To address the Office of the Secretary of Defense, the U.S. Air Force Biomedical Sciences Corps (BSC), and the Special Operations Command (SOC) need for an improved personal cooling system (PCS), Physical Optics Corporation (POC) proposes to develop a new Thermal-Exchange Dermal Interface (TEDI) technology. The proposed system is based on a unique integration of cooling and electrohydrodynamic tec ...

Oceanit will develop a method to increase the coupling factor in personal cooling systems. In our Phase I efforts the system will be designed and components selected. This system will meet all of the DOD requirements for the application

The Microclimate Cooling Unit will use magnetic energy to cause a temperature change in the exchanger to extract heat from the gel pack, which covers the primary area of heat loss on the human body at the neck and upper back, reducing the overall body temperature. Thermocouples will monitor the gel pack to allow the user to adjust the pack temperature to their needs.