Award Data

This STTR Phase II project will develop commercially viable atomic force microscope (AFM) probes fabricated from ultrananocrystalline diamond. The project will refine the processes developed in Phase I and bring contact and non-contact all-diamond probes to market. Probes using conducting diamond that are chemically and electronically tunable and have superb tribological properties will also be d ...

It is estimated that 220,000 people suffer cardiac arrest each year in the US, of whom only 10,000 survive to hospital discharge. The number of survivors could increase 10-fold if paramedical attention and/or defibrillation were available within a few min

This SBIR Phase II project aims to develop a commercial grade optical probe and system for FDA clinical trials and subsequent commercialization of a population-wide colon cancer screening test. An interdisciplinary research team of engineers, biologists, and clinicians has developed low-coherence enhanced backscattering (LEBS), an optical technique which enables sensing tissue microarchitectural c ...

DESCRIPTION (provided by applicant): The goal of this small business technology transfer application is to validate and commercialize an improved means of polyp detection during colonoscopy: spectroscopic microvascular blood assessment from the endoscopically normal mucosa. Missed lesions on colonoscopy are a major problem (conservatively estimated to be ~25% of adenomas and ~4-5% of carcinomas) w ...

The USAF is seeking to replace UV-susceptible adhesive that bonds the solar cell to a cover glass for enhancing conversion efficiency and to improve durability. Adhesives used for space solar modules need to meet many critical requirements including adhesion strength, optical transparency, thermal stability, and resistance against a broad range of radiation present in space environments includin ...

Environmental degradation of aerospace turbine components is a major concern for aircraft and power generation systems, and various surface treatments are utilized to extend the lifetimes of these critical components. This Phase II project is targeted toward extending the durability of thermal barrier coatings (TBCs) on hot section turbine components. TBCs are highly susceptible to degradation b ...

We will develop an efficient tool for formal verification of PowerPC 750 executables. The PowerPC 750 architecture is used in the radiation-hardened RAD750 flight-control computers that are utilized in many space missions. The resulting tool will be capable of formally checking: 1) the equivalence of two instruction sequences; and 2) properties of a given instruction sequence. The tool will automa ...

DESCRIPTION (provided by applicant): The long-term objective of this research is to develop a non-invasive approach for early assessment of de novo 3MH production in cancer patients as a way of assessing which patients are at high risk for future developme nt of skeletal muscle atrophy. The approach is based on the known increase in the rate constant for de novo production of 3-methylhistidine (3M ...

DESCRIPTION (provided by applicant): The long-term objectives of this proposal are to develop an inexpensive, totally non-invasive surrogate test for the 2-h oral glucose tolerance test (2-h OGTT) for the purpose of identifying individuals with pre-diabete s for preventive purposes. We believe that such a test can be developed based on oral administration of a 75-g 13C-labeled glucose solution adm ...

DESCRIPTION (provided by applicant): Chronic infections with hepatitis B or hepatitis C viruses are global health problems affecting hundreds of millions of people worldwide. Various commercial products of interferon alpha are approved in the United States for the treatment of adults with hepatitis B and hepatitis C. However, therapy with interferon involves multiple weekly injections via intramu ...