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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. he 3D Platelet Bank: A Clinical-grade, Scalable, 3D Microbioreactor Bone Marrow Mimetic for Platelet Production

    SBC: KIYATEC, LLC            Topic: NIBIB

    Project Summary Abstract The transfusion of platelets is a major component of the treatment of cancer patients undergoing chemotherapy and or bone marrow transplantstrauma patientssepsisand battlefield injuriesHoweverdue to a complete reliance upon donors as the only current approved source of plateletsand the strictshort shelf life and storage conditions of donorderived plateletscurrent supplies ...

    SBIR Phase II 2017 Department of Health and Human Services
  2. Polo box PLK Inhibitors Target Tumors Resistant to ATP Competitive Compounds

    SBC: PPI PHARMACEUTICALS, LLC            Topic: NCI

    Polo like kinase PLK is a central player in regulating entry into and progression through mitosis Many studies have validated PLK as an anti tumor drug target and its inhibition is potently anti proliferative to cancer cells However recent data suggests that there are two major disadvantages of the conventional approach to blocking the kinase activity of PLK First both general kinome ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. STTR Phase I: Marine Antifouling Deterrent Coatings for Quantum Paints

    SBC: ENGINEERED MARINE COATINGS LLC            Topic: MI

    This Small Business Innovation Research Phase I project will develop an environmentally benign yet highly effective marine antifouling coating for the American yacht market. The coating is a non-biocidal, foul release surface which does not require the vessel to move to obtain antifouling protection. It is a non-ablative multi-modal coating that will deter settling marine larvae when the vessel is ...

    STTR Phase I 2017 National Science Foundation
  4. Rational Design of sub-100 nm Polystyrene Particles With a Low Coefficient of Variation in Size

    SBC: Tetramer Technologies,L.L.C.            Topic: NA

    In this Phase I SBIR program, Tetramer Technologies will develop new, commercially attractive, highly monodisperse polystyrene latex standards in a variety of sizes (i.e. 30 nm to 100 nm) via emulsion polymerization processes that employ a surfactant and that are surfactant-free. Surfactant free emulsions will be stabilized through the use of ionic comonomers in the emulsion polymerization. The fo ...

    SBIR Phase I 2017 Department of CommerceNational Institute of Standards and Technology
  5. A Novel Millimeter wave mmw DNP EPR Front end Compatible with Versatile High field NMR Probes

    SBC: DOTY SCIENTIFIC, INC.            Topic: NIA

    A Novel Millimeter wave mmw DNP EPR Front end Compatible with Versatile High field NMR Probes Abstract There has been explosive growth in interest in Dynamic Nuclear Polarization DNP with Magic Angle Spinning MAS over the past five years because it has demonstrated S N gains exceeding two orders of magnitude at K compared to conventional MAS NMR and non spinning NMR of biological macro ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Ice Free Vitrification and nanowarming of large cartilage samples for transplantation

    SBC: TISSUE TESTING TECHNOLOGIES LLC            Topic: NIAMS

    Resurfacing of articular cartilage with cold stored osteochondral allografts is employed clinically for repair of trauma and osteoarthritis induced articular cartilage surface damage Chondrocyte viability of transplanted articular cartilage is accepted as one of the determinants of outcome following osteochondral allograft transplantation We have previously developed an ice free vitrification me ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Novel Topical HSP90 Inhibitor (CTXT-102) in the Treatment of Mild to Moderate Plaque Psoriasis

    SBC: Regranion, LLC            Topic: NIAMS

    PROJECT SUMMARY Psoriasis is a chronic inflammatory skin disease affecting approximatelymillion Americans that can become debilitating and severely impact quality of lifeWhile an estimatedof patients suffer moderate to severe disease forms that require systemic therapy with immune suppressants and ultraviolet phototherapythe majorityof patients exhibit milder symptomsFor these patientstopical agen ...

    SBIR Phase II 2017 Department of Health and Human Services
  8. An HXYZ-g HR-Fast-MAS probe for Dramatically Improved Biomolecular Structure Determinations

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    An HXYZ g HR Fast MAS probe for Dramatically Improved Biomolecular Structure Determinations AbstractLiquid state NMR spectroscopy is arguably one of the best tools for structure determination for soluble proteinsThe method provides atomic resolution for modest molecular weight proteins and or their complexesThe method begins to have difficulty when the molecular weight of the system causes slow mo ...

    SBIR Phase II 2017 Department of Health and Human Services
  9. SBIR Phase II: High-capacity Multimodal Anion-exchange Membranes for Purification of Biologics

    SBC: Purilogics, LLC            Topic: 400

    Project Summary This SBIR Phase II project will address the need for column chromatography products that can simplify the purification process for therapeutic biologics and increase purification speedThe rapid pace of biologics developmentdriven in part by growth of emerging markets such as personalized medicinehas increased the demand for affordable and fastsmall batch production runs in multi pr ...

    SBIR Phase II 2017 Department of Health and Human Services
  10. Stroke Treatment by Chemically-induced Hypothermia

    SBC: JT Pharmaceuticals, Inc.            Topic: 100

    ABSTRACTWhile acute stroke is a leading cause of human death and disability in the United Statesunfortunatelyclinical therapies for stroke are limited and unsatisfactoryThe overwhelming failures of stroke treatments in clinical trials strongly indicate thatto battle this multifaceted brain disordernovel strategies that target multiple cell types and afford different mechanisms of protection are ne ...

    SBIR Phase II 2017 Department of Health and Human Services

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