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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. MULTICHANNEL OCCULTATION PHOTOMETER

    SBC: Sets Technology Inc            Topic: N/A

    THIS PROJECT RESPONDS TO THE NEED FOR AN INFRARED PHOTOMETERTHAT IS CAPABLE OF ACQUIRING, WITH NEAR SIMULTANEITY, DATA IN AT LEAST TWO SELECTABLE PASSBANDS (1.0-TO-5.2 MICRONS AND 8-TO-13 MICRONS). THE PHOTOMETER MUST HAVE HIGH SENSITIVITY, OPERATE WITH A DUTY CYCLE OF ABOUT 100 PERCENT ON-SOURCE DURING CHOPPING, AND SAMPLE DATA CONTINUOUSLY FOR ONE HOUR AT 100 HZ. THIS PROJECT WILL DEVELOP A COMP ...

    SBIR Phase II 1992 National Aeronautics and Space Administration
  2. DEVELOPMENT OF A HYPERSPECTRAL GAS ANALYSIS SYSTEM (HYGAS)

    SBC: Sets Technology Inc            Topic: N/A

    THIS PROPOSAL RESPONDS TO TECHNICAL SUBTOPIC A91-021: TOPOGRAPHY, IMAGE INTELLIGENCE, AND SPACE EXPLOITATION, WHICH REQUESTS THAT UNIQUE APPROACHES FOR A REAL TIME KNOWLEDGE ENGINEERING BASED TACTICAL DECISION AIDS SYSTEM BE DEVELOPED INVOLVING PARALLEL COMPUTER ARCHITECTURES. THE OPPORTUNITY IS TO DEVELOP A SYSTEM THAT ACQUIRES AND TRANSLATES THE EXPERT'S KNOWLEDGE INTO A REPRESENTATION UTILIZABL ...

    SBIR Phase II 1992 Department of DefenseArmy
  3. COLD CORONAGRAPH FOR PLANETARY OBSERVATIONS

    SBC: Sets Technology Inc            Topic: N/A

    THE GOAL OF THIS PROJECT IS TO PRODUCE AN INSTRUMENT FOR ASTRONOMICAL OBSERVATIONS OF SOLAR SYSTEM OBJECTS IN THE THERMAL INFRARED REGION (5-30MUM), USING AN OPTICAL SYSTEM THAT IS CAPABLE OF RECONSTRUCTING AN IMAGE (WITH MOVABLE APODIZING MASKS) OF ELECTROMAGNETIC RADIATION COLLECTED BY A GROUND-BASED ASTRONOMICAL TELESCOPE. THE OPPORTUNITY IS TO APPLY TECHNIQUES, PREVIOUSLY USED AT VISIBLE WAVEL ...

    SBIR Phase II 1992 National Aeronautics and Space Administration
  4. PALYTOXIN PRODRUG ACTIVATION BY ANTIBODY-LINKED ENZYME

    SBC: Hawaii Biotech, Inc.            Topic: N/A

    PALYTOXIN IS AN EXTREMELY CYTOTOXIC LOW MOLECULAR WEIGHT NATURAL PRODUCT ISOLATED FROM SOFT CORALS OF THE GENUS, PALYTHOA. N-ACYLATED DERIVATIVES OF PALYTOXIN HAVE BEEN REPORTED TO BE UP TO 100-FOLD LESS CYTOTOXIC THAN THE UNMODIFIED TOXIN. PALYTOXIN N-ACYL DERIVATIVES WHICH CAN BE CONVERTED TO THE NATIVE TOXIN BY ANTITUMOR MONOCLONAL ANTIBODY- ENZYME CONJUGATES WILL BE PREPARED AND TESTED FOR ANT ...

    SBIR Phase II 1992 Department of Health and Human Services
  5. UREASE-LINED IMMUNOASSAY REAGENT STABILITY STUDIES

    SBC: Hawaii Biotech, Inc.            Topic: N/A

    UREASE OFFERS DISTINCT ADVANTAGES OVER OTHER ENZYMES FOR PREPARATION OF CONJUGATES USED IN ENZYME-LINKED IMMUNO-SORBENT ASSAY SYSTEMS. MOLECULAR DEVICES CORPORATION (MENLO PARK, CA) HAS CAPITALIZED ON THESE ADVANTAGES IN THEIR THRESHOLD SYSTEM. THIS IMPRESSIVE SYSTEM UTILIZES AVIDIN-BIOTIN TO "CAPTURE" ANALYTE-BOUND ANTIBODY-UREASE CONJUGATE COMPLEXES ONTO A MEMBRANE, WHERE THEY ARE QUANTITATED BY ...

    SBIR Phase II 1992 Department of DefenseArmy
  6. NEUROSPORA SECRETION EXPRESSION VECTOR DEVELOPMENT

    SBC: Hawaii Biotech, Inc.            Topic: N/A

    PRODUCTION OF RECOMBINANT PRODUCTS OF PHARMACEUTICAL AND INDUSTRIAL IMPORTANCE IN A VARIETY OF MICROORGANISMS HAS YIELDED A WIDE VARIETY OF BIOLOGICALLY ACTIVE PROTEINS. FUNGI OFFER THE ADVANTAGE OF REDUCED CULTURING AND DOWNSTREAM PROCESSING COSTS BECAUSE THEY ARE CAPABLE OF SECRETING PRODIGIOUS QUANTITIES OF PROTEIN. THE GENETICS AND BIOCHEMISTRY OF NEUROSPORA CRASSA ARE THE MOST FULLY CHARACTER ...

    SBIR Phase I 1992 National Science Foundation
  7. FUNGAL EXPRESSION OF DENGUE PROTEINS FOR VACCINES

    SBC: Hawaii Biotech, Inc.            Topic: N/A

    DENGUE VIRUSES ARE A LEADING CAUSE OF MORBIDITY THROUGHOUT THE TROPICS AND SUBTROPICS. ATTEMPTS TO DEVELOP LIVE ATTENUATED DENGUE VACCINES ANALOGOUS TO THE YELLOW FEVER VACINE HAVE BEEN UNSUCCESSFUL. IN AN EFFORT TO CONTRUBITE TO THE DEVELOPMENT OF A RECOMBINANT SUBUNIT DENGUE VACCINE, WE WILL INVESTIGATE EXPRESSION OF THE DEN-3 ENVELOPE GLYCOPROTEIN IN THE FILAMENTOUS FUNGUS NEUROSPORA CRASSA.

    SBIR Phase I 1992 Department of Health and Human Services
  8. CATALYTIC ANTIBODIES FOR PALYTOXIN PRODRUG ACTIVATION

    SBC: Hawaii Biotech, Inc.            Topic: N/A

    TRANSITION STATE ANALOG HAPTENS WILL BE PREPARED FOR THE ELICITATION OF ANTIBODIES WHICH CAN CATALYZE THE CONVERSION OF PALYTOXIN PRODRUGS TO PALYTOXIN.

    SBIR Phase I 1992 Department of Health and Human Services
  9. POLIO/DENGUE CHIMERAE FOR DENGUE VACCINE DEVELOPMENT

    SBC: Hawaii Biotech, Inc.            Topic: N/A

    WE WILL CONSTRUCT HYBRID POLIO/DENGUE VIRUS GENOMES IN ORDER TO DEVELOP A VACCINE FOR DENGUE VIRUS. IN THE CHIMERIC GENOMES, ONE OF TWO DENGUE VIRUS ENVELOPE GENE FRAGMENTS WILL REPLACE SEGMENT OF THE POLIO VIRUS STRUCTURAL PROTEIN GENES. SUCH CHIMERAE WOULD HAVE THE ABILITY TO REPLICATE IN THE GUT AND TO PRODUCE LARGE QUANTITIES OF IMMUNOGEN WITHOUT INFECTIOUS PARTICLE FORMATION, UNLIKE ATTENUATE ...

    SBIR Phase I 1992 Department of Health and Human Services
  10. BISPECIFIC ANTIBODY FOR DIRECTED DELIVERY OF TAXOL

    SBC: Hawaii Biotech, Inc.            Topic: N/A

    WE WILL ACHIEVE THE SELECTIVE DELIVERY OF CYTOTOXIC AGENTS THROUGH THE USE OF BISPECIFIC ANTIBODIES. TAXOL IS A PROMISING NEW ANTICANCER AGENT ISOLATED IN LOW YIELD FROM THE BARK OF THE PACIFIC YEW TREE, TAXUS BREVIFOLIA. THE APPLICANT WILL PREPARE A THIOETHER-LINKED BISPECIFIC ANTIBODY WITH DIAL SPECIFICITY FOR TAXOL AND HUMAN CANCER CELLS. IT IS ASSERTED THAT THIS BISPECIFIC ANTIBODY WILL POTENT ...

    SBIR Phase I 1992 Department of Health and Human Services

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