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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Software for the complete characterization of antibody repertoires: from germline and mRNA sequence assembly to deep learning predictions of their protein structures and targets

    SBC: DNASTAR, INC.            Topic: 400

    The B cell population in each individual produces an estimated 1010 different antibodies, collectively known as the antibody repertoire. This extraordinary diversity is essential for responding to the unique history of infections, vaccinations and cancer encountered over an individual’s lifetime. Conversely, regulatory errors in the system play a pivotal role in a host of auto-immune diseases. A ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. IND-enabling studies of an intranasal, single-replication M2SR influenza vaccine

    SBC: FLUGEN INC            Topic: NIAID

    ABSTRACT Influenza (flu) virus, an NIAID category C priority pathogen, causes a respiratory disease resulting in over 200,000 hospitalizations and ~ 36,000 deaths per year in the US, while global influenza pandemics have resulted in as many as 50-100 million deaths worldwide. To address this threat to public health, annual vaccination is recommended for all individuals aged over 6 months in the US ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Rapid structure-based software to enhance antibody affinity and developability for high-throughput screening: Aiming toward total in silico design of antibodies

    SBC: DNASTAR, INC.            Topic: NIAID

    Therapeutic monoclonal antibodies bind to specific regions of proteins called epitopes, which elicit cellular responses that treat or cure disease. Discovering therapeutic antibodies traditionally requires costly and labor- intensive, laboratory-based screening experiments. Computational approaches that select antibodies with the most desirable pharmaceutical properties are thus poised to improve ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. SBIR Phase II:Smart Shunt to Treat Hydrocephalus

    SBC: Madison Scientific, Inc.            Topic: MD

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is the development of an advanced electromechanical cerebrospinal fluid (CSF) shunt system for the treatment and monitoring of hydrocephalus. Hydrocephalus is caused by an accumulation of CSF occurs within the brain, often causing an increased pressure inside the skull. Most shunts used to re ...

    SBIR Phase II 2023 National Science Foundation
  5. Heterologous Synthesis of Polyunsaturated Fatty Acids for Aquaculture

    SBC: XYLOME CORP            Topic: 87

    Heterologous Synthesis of Polyunsaturated Fatty Acids for AquacultureUSDA SBIR Phase II Applicationth The United States is a minor aquaculture producer ranking 18 in global aquaculture productionin 2022 but it is the leading importer of fish and fish products. Even though U.S. aquaculture hasbeen estimated to be growing at a compound annual rate of 4.1% we still depend heavily uponimports. By valu ...

    SBIR Phase II 2023 Department of Agriculture
  6. A Framework for mHealth App Security and Privacy Analysis

    SBC: UBITRIX INTERNATIONAL, INC.            Topic: NLM

    PROJECT SUMMARY/ABSTRACT With the increased use of mobile health (mHealth) apps to improve health outcomes, protecting private health data is becoming increasingly important. These mHealth apps are offered by healthcare providers and used by patients for various reasons such as paying bills, scheduling appointments, sending messages to providers, accessing lab results, and viewing prescriptions an ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Targeting the CCR6-CCL20 pathway for treatment of psoriatic joint and entheseal inflammation

    SBC: XLOCK BIOSCIENCES, LLC            Topic: NIAMS

    Project Summary/Abstract The goal of this project is to develop and validate a novel therapeutic lead compound for the treatment of psoriatic arthritis (PsA). Chemokines orchestrate the migration of inflammatory cells during normal immune responses and are required for immune tissue development and homeostasis. When aberrant chemokine function occurs, improper recruitment of immune cells can lead ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Comprehensive Assessment of Cancer Theranostics Response

    SBC: AIQ GLOBAL INC            Topic: NCI

    Project SummaryTheranostics combines molecular targeted diagnostic and therapeutic radionuclides for imaging and ther- apy in advanced malignancies, with a projected US market of more than $6.7B. Currently, metastatic castra- tion-resistant prostate cancer (mCRPC) with FDA approved lutetium-177 (177Lu)-based peptide receptor targeting radionuclide therapy (PRRT), represents the largest market. Pro ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Plasma-Generated Hydroxyl Radicals for Analysis of Three-Dimensional Structures in Protein Therapeutics

    SBC: IMMUTO SCIENTIFIC            Topic: 400

    Abstract Immuto Scientific Inc. is developing a robust, automated benchtop instrument to perform high-throughput structural characterization of protein biotherapeutics in a fraction of time of traditional structural characterization techniques such as x-ray crystallography and cryo-EM. Protein-based biotherapeutics (such as antibodies, insulin, recombinant vaccines, etc.) are one of the most effec ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. One-click Automated 3D Treatment Planning for Radiopharmaceutical Therapy

    SBC: VOXIMETRY INC            Topic: 102

    PROJECT SUMMARY/ABSTRACT The Radiopharmaceutical Therapy (RPT) market is projected to surpass the Technitium-99m market by 2025, with an emphasis on metastatic prostate cancer, neuroendocrine tumors, and lymphoma. Driven by well- tolerated treatments and fewer side-effects, experts have estimated 150 new theranostic centers will be needed in the U.S. to deliver an estimated 50,000–200,000 treatm ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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