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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Ultrasonic Cardiovascular Measurements in Small Animals

    SBC: INDUS INSTRUMENTS            Topic: N/A

    Genetic manipulation is a developing tool in cardiovascular research, and much of this work isdone in mice. Ultrasound equipment designed for use on humans is not suitable for non-invasivemonitoring of cardiovascular parameters in mice due to small organ size (5 mm dia heart) and high heartrates (400-600 bpm). We propose to develop an instrument to measure cardiac output and myocardialfunction non ...

    SBIR Phase II 1996 Department of Health and Human Services
  2. Compact Proton Linac for PET Isotope Production

    SBC: Linac Systems            Topic: N/A

    The thrust of this proposal is the development of small, economical, table-top accelerators for thethe short-lived radioisotopes for the powerful medical diagnostic techniques, based on positron emis(PET), which have proven effective in monitoring physiological processes in the body, including braivisual processing. It draws upon recent advances in linear accelerator technology, a new rf-focusedst ...

    SBIR Phase II 1996 Department of Health and Human Services
  3. Ultrasensitive Nonisotopic Detection of RNA

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    Nonisotopic calorimetric and chemiluminescent technologies will be developed for use withribonuclease protection assays. The ribonuclease protection assay is an increasingly utilized techniquein molecular biology affording sensitive and quantitative measurement of mRNA levels. The ability ofthe assay to detect multiple mRNA levels simultaneously makes this technique a unique and powerfultool for u ...

    SBIR Phase II 1996 Department of Health and Human Services
  4. Miniature Solid-State Pumps for Biomedicine

    SBC: MicroFab Technologies Inc            Topic: N/A

    We will develop a new kind of pump for biomedicine. The pump is a small, piezoelectric device that has no conventional moving parts and is only a few mm in overall size. Digital electrical pulses produce individual pumping "strokes," and the pump can be operated at up to 20,000 hz. In our prototype, each pulse delivers approximately 51 pl of fluid; modeling studies indicate that larger and smaller ...

    SBIR Phase II 1996 Department of Health and Human Services
  5. In Situ Hybridization in Prenatal Diagnosis

    SBC: Perceptive Sciences            Topic: N/A

    We will develop significantly improved automated techniques for detecting the most commonly occurring cytogenetic abnormalities in interphase cells obtained by amniocentesis or chorionic villus sampling (CVS). Using DNA probes on interphase cells avoids the culturing required for routine cytogenetic analysis. This will reduce the time and cost of prenatal diagnosis and permit extension of the test ...

    SBIR Phase II 1996 Department of Health and Human Services
  6. Construction of Synthetic Muscle Specific Promoters

    SBC: Genemedicine, Inc.            Topic: N/A

    Somatic gene therapy is expected to provide new and improved therapies for many diseases.We are developing a new class of DNA-based therapeutics, "gene medicines" which are expected toprovide unique clinical benefits for the treatment of a broad range of diseases. Gene medicines utilizetissue-specific DNA expression vectors and novel vector delivery systems for the in vivo delivery oftherapeutic p ...

    SBIR Phase II 1996 Department of Health and Human Services
  7. Molecular Switch for Controlled Gene Therapy

    SBC: Genemedicine, Inc.            Topic: N/A

    This application describes construction of a vector for a gene therapy that can be incorporatedinto somatic cells in vivo and then regulated by administration of an oral, non-toxic, and widelybioavailable drug. The "gene switch" is based on a derived mutant of the progesterone receptor thatis activated by progesterone antagonists, but is not activated by progesterone agonists or other steroids.Thi ...

    SBIR Phase II 1996 Department of Health and Human Services
  8. DEVELOPMENT OF AN AUTOMATED SEGMENTED DNA SYNTHESIZER

    SBC: Genosys Biotechnologies, Inc.            Topic: N/A

    THIS GRANT WILL SEEK THE DEVELOPMENT OF AN AUTOMATED DNA SYNTHESIZER THAT IS ORDERS OF MAGNITUDE FASTER AND MORE COST EFFECTIVE THAN CURRENT COMMERCIAL DNA SYNTHESIZERS WHILE UTILIZING STANDARD DNA CHEMISTRY. THE GOAL IS TO AUTOMATE THE SOLVENT DELIVERY SYSTEM FOR THE WAFER DNA SYNTHESIS DEVICE AND TO EVENTUALLY AUTOMATE ALL ASPECTS OF THE DEVICE. ONCE COMPLETE AUTOMATION IS ACHIEVED, THE WAFER DN ...

    SBIR Phase II 1992 Department of Health and Human Services
  9. AN OCULAR NEUROTROPHIC FACTOR TO TREAT GLAUCOMA

    SBC: Houston Biotechnology, Inc.            Topic: N/A

    THE CILIARY GANGLION INNERVATES SEVERAL IMPORTANT EYE TISSUES, INCLUDING THE CILIARY MUSCLE AND BODY, AND HAS BEEN SHOWN TO REGULATE AQUEOUS OUTFLOW AND ACCOMMODATION. THE EYE DISORDERS, GLAUCOMA AND PRESBYOPIA, MAY INVOLVE THE CILIARY GANGLION THROUGH ITS REGULATION OF AQUEOUS OUTFLOW AND VISUAL ACCOMMODATION. A SUBSTANCE THAT COULD DIRECTLY AND SPECIFICALLY STIMULATE THE CILIARY GANGLION MAY BE ...

    SBIR Phase II 1992 Department of Health and Human Services
  10. AUTOMATED HOME TABLET AND CAPSULE DISPENSER

    SBC: Checkmate Engineering            Topic: N/A

    OF 28 MILLION AMERICANS OVER AGE 65, 8.5 MILLION LIVE ALONE. MORE THAN 50 PERCENT SUFFER FROM SUCH CHRONIC AILMENTS AS ARTHRITIS, HYPERTENSION, AND HEART DISEASE, ALL OFTEN REQUIRING DAILY MEDICATION. U.S. PUBLIC HEALTH RECORDS ESTIMATE THAT 125,000 DEATHS OCCUR EACH YEAR FROM THE MISUSE OF CARDIOVASCULAR DRUGS ALONE, AND THAT ONE IN EVERY TWO PATIENTS TAKING MEDICINE REGULARLY MAKES ERRORS SUFFIC ...

    SBIR Phase II 1992 Department of Health and Human Services
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