Award Data

DESCRIPTION (provided by applicant): The overall goal of the proposed SBIR program is to implement and evaluate a low cost retinal camera, the Laser Scanning Digital Camera (LSDC), in a system for diabetic retinopathy (DR) screening. Untreated DR has reached epidemic levels in underserved populations worldwide. As the LSDC has already demonstrated its readiness for DR screening in preliminary stud ...

DESCRIPTION (provided by applicant): An estimated 30% of chronic stroke patients with motor disabilities of the limbs are plegic in the hand or the foot - that is, they cannot move the hand or foot. While some plegic stroke patients have completely paralyzed muscles, without the ability to activate even minimally the plegic muscles ( profound plegia ), other plegic stroke patients are capable of p ...

DESCRIPTION (provided by applicant): Today, arsenic (As) poisoning is one of the major environmental threats worldwide as millions of human beings have been exposed to excessive arsenic through contaminated drinking water. The serious toxicity of arsenic has been well documented. Worldwide, communities demand novel separation technologies for the removal of arsenic from drinking water. Conventiona ...

DESCRIPTION (provided by applicant): This project will test the feasibility of a computerized speech perception assessment and training system (SPATS-AR) as a novel aphasia rehabilitation option. SPATS-AR will be developed by modifying existing software that has been found to be successful in improving speech recognition by hearing-impaired listeners (SPATS-HI) and by adult learners of English (SP ...

DESCRIPTION (provided by applicant): While it is well known that the brain undergoes rapid developmental changes from birth to early childhood, remarkably little is understood about the relationship between changes in brain size and composition and normal cognitive development. Yet we now know that several potentially debilitating disorders, among them the Autism Spectral Disorders, Attention Defi ...

DESCRIPTION (provided by applicant): The long-term objective of the proposed project is to design a low-profile, high-resistive, MRI-compatible dense array EEG sensor net for simultaneous dEEG/fMRI recordings in fields as high as 7 Tesla. This novel sensor net (256-channel InkNet) will use innovative conductive ink leads printed on polymer thick film (PTF) developed at the Analog Brain Imaging Lab ...

DESCRIPTION (provided by applicant): Stroke and heart attack are the leading causes of mortality and grave morbidity. The goal of this Fast-Track STTR grant application is to enable preclinical investigation of WE-thrombin, a bioengineered protein C activator enzyme for the treatment of severe, acute thrombotic diseases, in particular ischemic stroke. WE- thrombin is a fundamentally new thrombosi ...

DESCRIPTION (provided by applicant): This Phase I SBIR grant will support the initial commercial development of a single dose injectable biological product candidate, recombinant humanized anti-factor XI monoclonal therapeutic anticoagulant antibody, towards an investigational new drug (IND) application. The lead indication is severe bacterial sepsis, which is among the leading causes of mortality ...

DESCRIPTION (provided by applicant): Therapeutic Angiogenesis by Universal Donor Endometrial Regenerative Cells (ERC) Abstract The proposed study seeks to develop a practical, off the shelf, universal donor, cell therapy for an advanced form of peripheral artery disease termed critical limb ischemia (CLI). The major problem facing CLI patients is lack of proper circulation to the extremities. Al ...

DESCRIPTION (provided by applicant): Education Center for Adoptive Parents Online (ECAPO) Adoption has undergone dramatic change in the past 30 years, due largely to the complexity of contemporary adoptive relationships, which increasingly involve international, multi-ethnic, multi-racial, and foster care placements. Adoptive youth experience consistently high rates of behavior problems and psycho ...