Award Data

Project Summary Abstract Motor vehicle crashes are the leading cause of unintentional morbidity and mortality among children in the United States and a leading cause of brain injuryBrain injuries resulting from the child s head impacting surfaces in the vehicle during a frontal crash are a significant problem and head injury is the leading cause of death and serious injury for children in crashesC ...

Project Summary Abstract Proposed is an easy to useportable method for diagnosis of obstructive sleep apneaOSAusing non contact technology for use in clinical or home settingSignificanceAn estimatedmillion Americans have sleep apnea and recent epidemiological studies indicate the prevalence of this disorder is on the riseOSA is associated with several negative health outcomes including depression ...

PROJECT SUMMARY ABSTRACTDrug Design MethodologiesChris HoM DPh DThis SBIR will develop automated software to accurately estimate drug target binding affinity and selectivityThis capability is crucial to drug discoveryyet remains elusive in all current design toolsOur technology identifies favorable candidates and distinguishes problematic ones that could exhibit side effects due to weak or non sel ...

PROJECT SUMMARY Klebsiella pneumoniae is an increasingly prevalent drug resistant nosocomial pathogenCommonlyKpneumoniae isolates are carbapenem resistantwhich are referred to as carbapenem resistant EnterobacteriaceaeCREand present significantly less therapeutic intervention optionsFurthermorecommunity acquired infections associated with hypervirulent isolates of Kpneumoniae have emerged that are ...

Abstract The analysis of moleculesanalytesby liquid chromatographyLCis performed in all areas of healthcare from drug discovery and development to disease diagnosisHerewe propose a near universal LC detector utilizing a flame ionization detectorFIDthat responds with high sensitivity to all organic compoundsThis technology has the potential to speed up pharmaceutical development and allow for more ...

A novel inhibitor of the classical pathway of the complement system Abstract The classical pathway of the complement system is implicated in the pathogenesis of a number of human autoimmune diseasesincluding systemic lupus erythematosusrheumatoid arthritisalloantibody mediated transplant rejection and autoimmune hemolytic anemiaDespite a large body of literature documenting the role of the complem ...

PROJECT SUMMARY Bloodstream infectionsBSIsrepresent a very serious clinical manifestation that can be caused by a variety of bacterial and fungal pathogensmany of which have been associated with high rates of mortalityPhysicians caring for patients with BSIs are challenged with having very limited time to make an effective diagnosisincluding identification of the causative agent and determination ...

Abstract Koronis Biomedical TechnologiesKBTand its collaborates propose to develop a wearable system to monitor patient coughs at homeThe frequency and intensity of a patient s cough can be instrumental in the continual monitoring and treatment of many chronic respiratory conditionsCurrent clinical methods are limited and lack the ability to capture long term trends in the cough frequency and seve ...

Abstract The goal of this SBIR FastTrack application is to deliver an augmented realityARplatform technology that displays an interactiveD cardiac hologram to make ablation procedures simpler and saferWorld widecardiac ablations are used as therapy formillion arrhythmia patients every yearThere ishoweversignificant skill required to perform these procedures and only a handful of cases can be perfo ...

Abstract Koronis Biomedical Technologies CorporationKBTproposes to develop a non contactbiologically safe radar system capable of monitoring the respiration rate and heart rate of neonatesPremature infants are a particularly vulnerable population within pediatrics that demonstrate an impending clinical change through subtle alterations in vital signs and therefore for whom constant monitoring is p ...