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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Using Connected Play To Engage Learners In Computational Thinking Practices Through Collaborative Problem Solving

    SBC: Makefully, LLC            Topic: 91990020R0006

    This project will develop a prototype that extends Makefully, a collaborative digital and physical multi-player puzzle-solving board game for math and computer science, with a focus on integrating music. The Phase I prototype will include additional physical and digital play modules and an adaptive component that provides feedback to students as they progress through the game to inform their learn ...

    SBIR Phase I 2020 Department of EducationInstitute of Education Sciences
  2. Towards a New Generation of Glycoengineered Pneumococcal Bioconjugate Vaccines

    SBC: VaxNewMO            Topic: NIAID

    PROJECT SUMMARY Pneumococcal conjugate vaccines (PCVs), composed of a pneumococcal polysaccharide covalently linked to a carrier protein, are life-saving prophylactics used to prevent pneumococcal disease. Importantly, PCVs provide immunity for all age groups, including, infants and children under the age of two, which is not the case for purely polysaccharide vaccines. Like all conjugate vaccines ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Auditory Brain Training to Enhance Satisfaction and Usage of New Hearing Aids by Older Adults

    SBC: customized learning Exercises for Aural Rehabilitation (clEAR) LLC            Topic: R

    Abstract Hearing loss is the third most common health condition for older adults in the US, and if untreated, may lead to social isolation, depression, cognitive decline, and fear of being home alone. Sadly, over 48% of seniors who purchase hearing aids cannot adjust to them well enough to use them daily and 31% report never using them. This is a tragic state of affairs, especailly since a Nationa ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Heterocyclic Inhibitors of QcrB as Novel Drugs for Tuberculosis

    SBC: FIMBRION THERAPEUTICS, INC.            Topic: NIAID

    Tuberculosis (TB) is caused by infection with the bacterium Mycobacteria tuberculosis (Mtb) and is the leading cause of mortality in the world for a single infectious agent. As efforts to treat TB expand, the prevalence of multidrug resistant TB (MDR-TB), which are resistant to the frontline standard of care (SOC) antibiotics rifampicin and isoniazid, is increasing. Despite the dire need for new t ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. An Improved Intra-Arterial Delivery Platform for Glioblastoma Multiforme

    SBC: UNandUP, LLC            Topic: 102

    The value of lives lost to cancer-related deaths in the United States is expected to exceed $1.4 trillion by 2020. Of all cancers, glioblastoma multiforme (GBM) is one of the most aggressive types of central nervous system tumors with more than 95% of victims dying within 5 years. Left untreated, median survival is only 3 months. While the incidence rate is 3.2 per 100,000 person-years, GBM is the ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. A High Sensitivity Multiplexed Immunoassay for Aging-Related Inflammation Biomarker Quantification

    SBC: Auragent Bioscience, LLC            Topic: NIA

    Abstract Age is the number one risk factor for the major chronic diseases in the developed world. Currently, 81% of adults in the United States are afflicted with one or more chronic diseases. As the average age of the population of the United States continues to grow, we will be faced with a significant disease burden if the percentage of adults with chronic disease remains the same. It is now we ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Insect cell lines for glycoprotein structural biology and mannose-dependent protein drugs

    SBC: Glycobac, LLC            Topic: 300

    Project Summary / AbstractThe objective of the proposed research is to create and validate new insect cell lines that can be used to produce glycoproteins (proteins with attached sugars to their surface) specifically for structural biology research. We will engineer insect cell lines so they produce sugar structures that can be removed under non-denaturing conditions, thereby retaining the three-d ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Drug target identification using CRISPRi/a screening

    SBC: BIOIO, LLC            Topic: 400

    ABSTRACT As phenotypic screening makes a comeback in drug discovery, its major issue is drug target identification. There aren’t good generalizable approaches to do target identification for compounds of interest. Identifying how a new drug works at the molecular level is critical for improving it, which is often needed to give it the best chance of ultimately being both safe and effective in pa ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Fluorescence-based sequence-specific imaging of RNA modifications

    SBC: MEDIOMICS, LLC            Topic: 400

    Abstract RNA modifications are found in rRNA, tRNA, mRNA, snRNA and miRNA in all three primary phylogenetic domains. Recent technological advances that allowed mapping of selected RNA modifications on a transcript-wide scale revealed wide-spread distribution of N6-methyladenosine (m6A), pseudouridin (Ψ), N1-methyladenosine (m1A), 5-methylcytosine (m5C), ribose 2’-O- methylation (Nm) on mRNA. Fo ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Targeting multiple signaling pathways for tinnitus prevention and treatment

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    Subjective tinnitus is the perception of a phantom sound, which negatively impacts the quality of life for millions of people worldwide. Despite the great demand for remedy, there are no FDA-approved drugs to prevent or treat tinnitus. Possible causes of tinnitus are complicated. The current view is that hyperactivity in the central auditory nervous system contributes to the majority of tinnitus c ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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