Award Data

DESCRIPTION provided by applicant This Phase II SBIR finalizes development and clinically tests Neo ET Clear an Actuated Low Stress Endotracheal Tube ETT Cleaner to Improve Neonate Lung Function Neo ET Clear suctions mucus from mm diameter neonatal endotracheal tubes with significantly reduced deleterious impact on lung function and mechanics as compared to current methods includin ...

DESCRIPTIONprovided by applicantNovel therapies for the treatment of Chikungunya virusCHIKVinfections are urgently needed to address the alarming spread of this pathogen across the AmericasWe have identified a series of potentselectiveand orally bioavailable inhibitors of CHIKV replicationIn this Direct to Phaseprojectwe will optimize this series of CHIKV inhibitors to Pre Development stage and ad ...

DESCRIPTION provided by applicant Pulmonary drug delivery has emerged as a noninvasive alternative route for the treatment of lung diseases asthma COPD CF and lung cancer In order to obtain the desired level of effectiveness and safety of the inhaled drugs an appropriate deposition on the targeted region and subsequent absorption in the targeted region is vital Multiscale multidisciplin ...

Project Summary Asthma is a chronic lung disease that causes the airways in the lungs to become inflamed making it difficult to breathe and leading to episodes of intense coughing and wheezing The prevalence of asthma has increased rapidly over the past several decades and more than in Americans are now living with the disease While there is no cure for asthma the symptoms of the disease ...

ABSTRACT Diabetes is the leading cause of nontraumatic lower extremity amputations in the United States Diabetic foot ulcers DFUs are responsible for more hospitalizations than any other diabetic complications Currently even the best available treatments achieve only a healing rate for these wounds and this healing is often only temporary with a chance of recurring Our company has ...

DESCRIPTION provided by applicant The goal of the Phase I study is to determine the feasibility of piloting a low cost Real Time Location System RTLS for use in healthcare based on a novel technology known as Near Field Electromagnetic The proposed QHealth system promises to support a number of healthcare applications such as equipment management workflow optimization hand hygiene complian ...

DESCRIPTION provided by applicant ParaTechs Corporation aims to provide researchers with advanced technology and methods to simplify procedures for laboratory animal models While actively supporting efforts to `reduce replace and refineandapos animal use ParaTechs provides safe and efficient alternatives for surgical procedures We have already brought to market a nonsurgical embryo transfe ...

DESCRIPTION provided by applicant Maps of where small chemical fragments bind to proteins are proving to be an important source of information for life sciences research most particularly in drug discovery For example such maps are used to discover binding andquot hot spotsandquot by fragment clustering identify how fragment binding patterns differ among protein structure variatio ...

DESCRIPTION provided by applicant According to the CDC in ischemic heart disease is the leading cause of death worldwide and in the US approximately patients died of ischemic heart disease It is well established in clinical practice that recanalization of he infarct related artery IRA using percutaneous coronary intervention PCI enhances myocardial salvage and outcomes in pa ...

Approximately individuals worldwide suffer from cystic fibrosis CF a debilitating ion transport disease characterized by abnormal mucus secretion primarily involving the lungs Following years of symptom management as the only treatment option Kalydeco ivacaftor or VX and Orkambi a combination of ivacaftor plus lumacaftor VX were approved by the FDA to treat the underlyi ...