Award Data

DESCRIPTION (provided by applicant): Cancer continues to be a leading cause of death in the U.S. and in many other countries. Cancers develop and spread within the body when tumor cells are not detected or destroyed by the immune system. Although certain new therapies hold promise, current cancer treatments, including chemotherapy and radiation therapy, tend to kill cells non-selectively and can ...

The Air Force has demonstrated that a water is capable of extinguishing comparable H2O2 oxidizer fires with 23 pounds of water vs 67 pounds of halon. Recent advances in sensor technology make it possible to detect an H2O2 leak prior to ignition, or to rapidly detect ignition in order to initiate fire protection system water flow. Recent findings by Streamline Automation also indicate that fire e ...

DESCRIPTION (provided by applicant): Paclitaxel (Taxol) and doxorubicin (DOX, Adriamycin) are chemotherapeutic drugs used in treatment of metastatic breast cancer. When used individually, they produce a 30-40 percent response rate. When combined, using high doses of DOX (450-550 mg/m2), the response rate is increased to 85-95 percent. This represents a significant improvement in tumor responsivene ...

This proposal is for the design and development of a challenging, adaptable, and extendible AI system for use in state-of-the-art computer-based wargames. The development will result in a 3rd generation computer wargame based on modern air power conflict and the ability to apply the technology developed for this project in other wargames ranging from tactical ground-based warfare to naval conflic ...

DESCRIPTION (provided by applicant): Alcoholic liver damage (ALD) is among the ten most common causes of death in the USA. The liver may be uniquely sensitive because it metabolizes ethanol at a high rate. This generates acetaldehyde intracellularly, damaging cell components directly, and/or inducing apoptotic cell death. Although some plant natural products are protective it would be of value to ...

DESCRIPTION (provided by applicant): The actions of acamprosate, memantine and mecamylamine in alcohol dependence suggest that glutamate receptors (specifically NMDARs and mGluRSs) and acetylcholine receptors (specifically nicAChRs) are potential molecular targets for prevention of relapse. Many natural products from plants interact with these receptors, and the specific aim of phase 1 is to gene ...

DESCRIPTION (provided by applicant): Dyslexia is one of the most common learning disabilities affecting about 10% of the population. As many as 80% of all people diagnosed with learning disabilities are dyslexic. If diagnosed at all dyslexia is typically detected in children between age 5 and 8 after they have fallen two grade levels behind in reading. This difficulty in school often results in th ...

DESCRIPTION (provided by applicant): Genetics has provided one of the most discerning and powerful approaches to the dissection of biological function and Drosophila has served as a major model organism for such analyses, many of which have been probed processes relevant to human health. Now gene inactivation by RNAi is revolutionizing genetic approaches. By making possible extremely rapid whole g ...

DESCRIPTION: A novel platform biotechnology, "natural products genomics" for seeking plant-based medicines has been developed which utilizes high throughput screening to identify active compounds in large populations of mutant plant cell cultures. This technology likely accesses the entire range of metabolic products of which the plant is capable. In this regard, plants, particularly their roots, ...

DESCRIPTION (provided by applicant): This project will develop, evaluate and distribute an interactive multimedia program to provide interactive instruction about the human nervous system using a programmed learning format. The program will also provide extensive self-testing for the competencies to be acquired through interaction with the software program. The specific aims of the project are: A) ...