Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Development of a Novel Therapeutic for Alzheimer' Disease

    SBC: CoPlex Therapeutics, LLC            Topic: NIA

    DESCRIPTION (provided by applicant): Traditional approaches to drug development for Alzheimer's disease are becoming increasingly expensive and in many cases disappointingly unsuccessful. Based on preliminary in vitro and in vivo studies we have identifieda novel lactam derivative of the commonly prescribed 1,4 dihydropyridine calcium channel blocker nifedipine (1-acetyl-2,4- dimethylbenzo[c] ...

    STTR Phase I 2012 Department of Health and Human Services
  2. Long-Term Broad-Spectrum Prevention of Implant-Related Infections

    SBC: Biomedical Development Corporation            Topic: NIA

    DESCRIPTION (provided by applicant): Deep wound infection following total joint arthroplasty is a devastating complication for physician and patient, a leading cause of morbidity, and a significant economic burden to the healthcare system. With an aging population and increased life expectancies, the number of arthroplasties is expected to rise dramatically over the next 20 years. The growing numb ...

    STTR Phase I 2012 Department of Health and Human Services
  3. Delayed Tolerance Induction in Living Related Donor Renal Transplant Recipients

    SBC: REGENEREX, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): We have developed a protocol that reproducibly induces transplantation tolerance in individuals undergoing a living related donor kidney transplant. Three subjects have been off all immunosuppression for 10 months, 2 months, and 1 month respectively and have remained chimeric with stable renal function. Two additional chimeric subjects are in various stages of ...

    STTR Phase I 2012 Department of Health and Human Services
  4. Medical Sensor Applications of Tunnel Magnetoresistance (TMR)

    SBC: KORONIS BIOMEDICAL TECHNOLOGIES CORP.            Topic: NIDCD

    DESCRIPTION (provided by applicant): Koronis Biomedical Technologies (KBT) proposes to develop a novel tunneling magnetoresistance (TMR) sensor for use in medical devices. TMR technology delivers improvements in magnetic sensor size, sensitivity, and noiserejection that represent an opportunity to significantly enhance the performance of a variety of medical devices that currently rely on traditio ...

    STTR Phase I 2012 Department of Health and Human Services
  5. Development of a Plasma Biomarker of Alzheimer's Disease

    SBC: SCOUT DIAGNOSTICS            Topic: NIEHS

    DESCRIPTION (provided by applicant): The major barriers to preventing or treating Alzheimer's disease (AD) are its unknown pathogenesis/etiology and the lack of an objective, sensitive and specific biomarker of the disease, particularly at the early stageswhen therapeutic interventions would likely have the greatest efficacy. The basic hypothesis of this application is that plasma levels of a ...

    STTR Phase I 2012 Department of Health and Human Services
  6. Mitochondrial DNA repair agents for acute lung injury

    SBC: EXSCIEN CORPORATION            Topic: NHLBI

    DESCRIPTION (provided by applicant): Drug development for acute lung injury (ALI) has been marred by unfulfilled expectations. Perhaps best illustrating this unsatisfactory situation is the history of therapeutic strategies directed at inhibition of reactive oxygen species (ROS). While decades of laboratory and clinical studies make it clear that ROS are pathogenically important across the entire ...

    STTR Phase I 2012 Department of Health and Human Services
  7. Neurocognitive Training to Improve Executive Function

    SBC: KORONIS BIOMEDICAL TECHNOLOGIES CORP.            Topic: NCATS

    DESCRIPTION (provided by applicant): In this Phase I STTR project Koronis Biomedical Technologies (KBT) in close collaboration with the Zelazo Lab at the University of Minnesota proposes to develop an electroencephalography (EEG) based neurocognitive training tool to enable individuals to improve neurocognitive processes associated with executive function (EF). Processes involved in self-control a ...

    STTR Phase I 2012 Department of Health and Human Services
  8. The Bumps, a device for rapid, non invasive quantification of touch sensation

    SBC: Neuro Devices, Inc.            Topic: NCATS

    DESCRIPTION (provided by applicant): This application describes an elegantly simple, pocket size device, called the Bumps that rapidly quantifies the important sensation of touch on the fingers in micrometer ( m) units. This high sensitivity differentiates the small variations f touch sensation that exist between healthy subjects and can detect minor reduction of touch sensation in fingers of ...

    STTR Phase I 2012 Department of Health and Human Services
  9. Transdermal Naltrexone for Opiate Addiction and Alcoholism

    SBC: ALLTRANZ, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): According to the National Survey of Drug Use and Health (NSDUH) of 2008, 7.2 million Americans are in need of treatment for Substance-Related Disorders (SRDs), and a large proportion of those need treatment for opiate pain reliever, heroin, and alcohol addiction. Naltrexone (NTX), an opioid antagonist, is currently used in oral tablet form to help maintain opio ...

    STTR Phase I 2012 Department of Health and Human Services
  10. Delivery system development for a reservoir targeted Lyme disease vaccine

    SBC: FoodSource Lure Corporation            Topic: NIAID

    DESCRIPTION (provided by applicant): The incidence and geographic distribution of Lyme disease in the U.S. has increased steadily since its first description in 1977. Efforts to stem the spread of the disease through controlling the population of its tickvector and/or the mouse reservoirs of the disease have met with only limited success. The only approved human vaccine to protect against Lyme di ...

    STTR Phase II 2012 Department of Health and Human Services
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