Award Data

PROJECT SUMMARY Many pathogens, such as severe acute respiratory coronavirus 2 (SARS-CoV-2) and Mycobacterium tuberculosis, spread via aerosol transmission and inflict global public health and economic consequences. SARS-CoV-2 has infected over 450 million people, led to over 6 million fatalities, and caused major economic losses. The tuberculosis-causing bacterium and longstanding global health e ...

PROJECT SUMMARYSouth Rampart Pharma (SRP) is an early clinical-stage company focused on developing SRP-001, a novel non-opioid designed to treat moderate-to-severe acute and chronic pain without the dose-limiting hepatotoxicity of acetaminophen and nephrotoxicity of NSAIDs, and the misuse and addictive potential of opioids. SRP-001 is currently in Phase 1 trials where interim data support the expe ...

AbstractLung diseases ranging from cancer to chronic obstructive pulmonary disease (COPD) affect large numbers of men and women worldwide each year. Current news reports describe the respiratory impact of COVID-19; likewise, the past year has seen extensive coverage of the respiratory problems caused by vaping. Worldwide, lung diseases of all types result in millions of deaths per year at a stagge ...

SUMMARY Alzheimer’s disease (AD) and related dementias are devastating conditions that affect millions of people, but no effective treatment options exist. Studies are currently being performed as part of the funded Phase II STTR parent award to test efficacy of a potential AD therapeutic, OL-003, in two additional animal models and assess pharmacology and toxicology. The overarching goal of the ...

SUMMARY Glioblastoma (GBM) is the most common primary tumor of the CNS with limited treatment options and a poor clinical prognosis. Standard of care treatment, including surgical resection, radiation therapy and concurrent temozolomide (TMZ) treatment followed by adjuvant TMZ, produces a median survival in newly diagnosed GBM of ~15 months. Tumor recurrence happens due to therapy resistant tumor ...

Glioblastomas are very aggressive tumors of the central nervous system (CNS) with a median patient survival of about 16 months. Therapeutic options for glioblastoma patients are very limited mostly because the majority of potential anti-cancer drugs do not cross the blood brain barrier (BBB). In addition, recently tested immunotherapies including immune checkpoint inhibitors, tumor vaccines, and a ...

PROJECT SUMMARY The drug development pipeline is plagued by unacceptable rates of attrition due in large part to toxicities that are not identified in pre-clinical stages of development. While peripheral neuropathy remains a common toxic side-effect of new drugs, such toxicity is typically only first identified during late-stage preclinical development or even early clinical trials. Drug-induced n ...

SUMMARY BioAesthetics is developing a novel acellular graft for improved abdominal wall reconstruction (AWR). A hernia is a condition in which an internal organ pushes through an opening in the muscle or tissue that holds it in place. More than one million hernia repair surgeries occur annually in the US, corresponding to healthcare costs of $48 billion annually. Hernia repair is the most common o ...

SUMMARYPOP is an area of significant unmet medical need where patients and doctors alike are desperate for a safe and effective solution. Worldwide, over 1 billion women are impacted by POP, as it affects 33% to 50% of all women. POP symptoms can have significant negative impacts on womenandapos;s physical, mental, and sexual health, family relationships, daily living, and quality of life. Surgica ...

PROJECT SUMMARYMore than 5 million U.S. patients take oral anticoagulants daily for the prevention and treatment of thromboembolic events. Most of them are outpatients in need of frequent at‐home monitoring of anticoagulant therapy. According to the National Action Plan for Adverse Drug Event (ADE) Prevention, anticoagulants are “the most common causes of ADEs across health care settings”. 3 ...