Award Data

Creare is developing a miniature power system for NOA weather monitoring stations in remote locations. This system can provide electric power continuously from naturally occurring temperature differences that exist between ambient air and water in environments such as the Arctic Ocean and the Great Lakes. Generating power directly from these temperature difference uses the atmosphere and ocean/lat ...

The United States has a vast network of pipelines used for fuel transport. This infrastructure, installed in 1950–1970, is one of the largest in the world. Yet poor/missing records of the materials used, combined with the overall age and associated environmental degradation effects, often results in unsafe operation. Current non-destructive inspection techniques are only capable of detecting mat ...

Our goal is to identify novel parasite derived immunomodulatory tolerogenic adjuvants that can suppress pro inflammatory and autoimmune disease statessuch as typediabeteswhich has no disease modifying treatmentParasitic helminths establish chronic infection by modulating host innate and adaptive immune responsesdown regulating T effector cellsstimulating Thand or inducing regulatory B and T cellsS ...

High throughput screeningHTShas emerged as a leading method of drug discovery and development in the pharmaceutical industryacademiaand at the NIH National Center for Advancing Translational SciencesNCATSHTS relies on the ability to rapidly screen tens of thousands of compounds to identify the most promising drugs and their dose response curvesHTS isof necessityhighly automated and demands mechani ...

Cognitive decline is a major quality of life concern for many cancer survivorsThevarious available treatments affect individuals differentlyand research has unfortunately provided little guidance on how specific treatments impact neurocognitive functionTo help researchers fill this information gap and ultimately provide guidance to doctors and patientsa neuropsychological assessment system that is ...

Project Summary Rodent-borne viral outbreaks are increasing in both frequency and impact. Hantaviruses are transmitted through the excreta of infected rodents and, when aerosolized, infect humans. In the Americas, hantavirus infection leads to hantavirus cardiopulmonary syndrome (HCPS), a devastating condition that features rapid onset of pulmonary edema, respiratory failure and cardiogenic shock. ...

Project Summary Systemic sclerosis (SSc) is a systemic autoimmune disease that results in widespread fibrosis of the skin and internal organs, vascular dropout and autoantibody formation. SSc has the highest case fatality rate of any systemic autoimmune disease and there remain no FDA-approved therapies. Our data and that of others indicate that the innate immune system is the major driver of fibr ...

Development Commercialization of a Sensing Device to Detect Vaping Summary The use of e cigarettes or vaping has been steadily increasing since its introductionWhile potentially a tool to wean cigarette smokers from combustible tobaccoone consequence of the introduction of these devices has been the adoption of vaping by adolescentsWhile companies that offer vaping instruments for sale note that t ...

PROJECT SUMMARY ABSTRACTInSight Surgical TechnologiesLLCis a newly formed start up founded by senior members of a long standing NIH funded research effort to develop intraoperative image updating that maintains accurate image correspondence with the surgical field throughout a procedureThe effort has led to research innovations that have generated an intellectual propertyIPportfolio ofissued andpe ...

Project Summary Bacterial resistance has reached alarming levels in the US and other parts of the world in the past decadeThe increase in bacterial infection with drug resistantDRpathogens are resulting in increasing healthcare costs and a decline in positive clinical outcomesSerious infections leading to sepsis remain a public health concernIn the United States aloneapproximatelypatients develop ...