Award Data

DESCRIPTION (provided by applicant): The aim of the proposed research is to develop an enabling technology that will allow development of a molecular diagnostic for identification and discrimination among closely related bacterial species that cause signif icant disease at low microorganism numbers. The technology will be advanced through the development of a diagnostic system for detection of spe ...

Cities must perform detailed assessments of sidewalks and streets, including curb ramps, pedestrian signals, crosswalks, street furniture, and other components to determine compliance with the Public Rights-of-Way Accessibility Guidelines. However, current assessment methods are inadequate or unreasonable due to time and resources required. The objectives of this project are to: 1) develop elect ...

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DESCRIPTION (provided by applicant): Major health disparities in chronic disease control and outcomes exist among Latinos, the fastest growing segment of the U.S. population. If these disparities continue, demographic trends will magnify their adverse health, societal, and economic impact. Chronic disease control often requires successful management of multiple prescription medications, yet many p ...

DESCRIPTION (provided by applicant): Much efforts in gene expression analysis in the past have been focused mainly on the messenger RNAs (mRNAs), thanks to the availability of Differential Display (DD), SAGE and DNA microarray technologies, which all targ et the poly(A) tails present in most eukaryotic mRNAs. The recent discovery of a large microRNA population begged the question of whether there ...

THE PAST DECADE HAS SEEN A GREAT IMPETUS IN THE SEARCH FOR TUMOR MARKERS FOR THE DETECTION AND MANAGEMENT OF CANCER. THIS SEARCH HAS LED TO THE DISCOVERY OF SEVERAL OTHER CARCINOFETAL PROTEINS SUCH AS VARIENTS OF CEA AND ALPHA FETOPROTEINS. THE TUMOR MARKER, TENNESSEE ANTIGEN, APPEARS TO DIFFER SIGNIFICANTLY FROM CEA IN MOLECULAR WEIGHT, MOBILITY IN IMMUNOELECTROPHORESIS, CARBOHYDRATE RESIDUE CONT ...

A NEW TUMOR-ASSOCIATED ANTIGEN, CALLED TENNESSEE ANTIGEN (TAG), HAS BEEN ISOLATED FROM 95% OF 154 PRIMARY HUMAN GASTRAINTESTINAL TUMORS. IN 208 PATIENTS WITH COLORECTAL CARCINOMA, 81% SHOWED ELEVATED LEVELS OF TAG IN THEIR SERUM. IN THIS PROPOSAL, TAG WILL BE ISOLATED FROM EXTRACT OF ADENOCARCINOMA OF HUMAN GASTROINTESTINAL TRACT. MONOCLONAL ANTIBODIES (MOAB) AGAINST TAG WILL BE PRODUCED. SPLEEN C ...

DESCRIPTION (provided by applicant): MDI-301 is a synthetic retinoid. MDI-301, like RA, induces collagen synthesis and reduces expression of collagen-degrading matrix metalloproteinases in the skin. This agent also induces epidermal thickening. However, un like RA, MDI-301 is non-irritating when applied topically. In a recent study we showed that MDI-301 was effective in promoting the healing of s ...

DESCRIPTION (provided by applicant): Our long-term research goal is to develop an ophthalmic, nanofiber-based, biodegradable device that will provide extended release of therapeutic agents to the posterior segment of the eye via transscleral and intravitr eal approaches. This platform device will address the major technical problem in the treatment of posterior eye diseases (diabetic retinopathy, ...

DESCRIPTION (provided by applicant): Bone marrow and gastrointestinal mucosa are highly sensitive to radiation exposure. Radiation-induced damage to bone marrow and the gastrointestinal tract could be lethal in events such as nuclear accidents or radiation terrorism, depending on radiation doses, exposure rate and quality. No truly satisfactory radioprotective drugs are yet available. The phospho ...