Award Data

DESCRIPTION (provided by applicant): Nearly 20 years ago, partially as a response to leveraging the genomics research the NIH invested in the development of gene array technologies. These gene chips' enabled great breakthroughs in our understanding of the underlying biological processes that occur in cells and tissues. These increased understandings have already led to new therapies that affect ...

DESCRIPTION (provided by applicant): We propose to develop an inexpensive high-throughput means of selecting and identifying antibodies to both unmodified and modified protein, peptide, and non-peptide antigens. The specific goals of this proposal are to complete a proof-of-concept using aqueous droplets in an oil emulsion for identification and isolation of scFv antibodies. Compartmentalization ...

DESCRIPTION (provided by applicant): Our recent series of innovative randomized trials evaluating the efficacy of various strategies for training clinicians to use evidence based therapies in alcohol and drug abuse has indicated that while both in-person workshop and computer-assisted training can impart the skills necessary to deliver Twelve Step Facilitation, they are by no means sufficient in e ...

DESCRIPTION (provided by applicant): This SBIR Phase I project will determine the feasibility of applying polypeptide multilayer nanofilm technology to synthetic biomatrix development and commercialization. These nanofilms are a type of surface coating for cell and tissue culture. Immediate in vitro uses of synthetic biomatrix materials include many areas of basic medical research, diagnostic test ...

Cities must perform detailed assessments of sidewalks and streets, including curb ramps, pedestrian signals, crosswalks, street furniture, and other components to determine compliance with the Public Rights-of-Way Accessibility Guidelines. However, current assessment methods are inadequate or unreasonable due to time and resources required. The objectives of this project are to: 1) develop elect ...

DESCRIPTION (provided by applicant): The long-term clinical objective of this proposal Multimodal Diagnostic and Therapeutic Nanoparticles for Non-Hodgkin's Lymphoma is the development of a novel therapeutic and diagnostic drug delivery technology for sp ecific use in the treatment of non-Hodgkin's lymphoma. The combination of non-invasive imaging techniques such as MRI and targeted drug deliver ...

DESCRIPTION (provided by applicant): Tissue engineering currently has little discipline in assessing the efficacy of biomaterials through in vivo experiments. This lack of discipline poses a serious challenge to the community as it will soon be inundated with scaffold biomaterials and alternative progenitor and stem cells. The community needs to establish a systematic way of evaluating which combi ...

DESCRIPTION (provided by applicant): This project aims at developing software technology capable of automating bone histomorphometry, which at the moment is mostly done manually through cumbersome and laborious interactive processes. Our plan is to use state-of-the-art image processing techniques to automate detection, measurement and quantification of biological effects directly over the stained ...

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the single most common cause of death in the United States. Although the study of the CVD has greatly benefited from the use of gene-targeted transgenic mouse models, these small rodents do not accurately reflect human cardiovascular physiology. The Rabbit would be an excellent animal model for CVD research, considering its many ...

DESCRIPTION (provided by applicant): Statins are the most prescribed drugs in the world. Their efficacy in primary and secondary prevention of cardiovascular disease as well as beneficial pleiotrophic and anti-inflammatory effects have fostered increasingl y aggressive usage and dosage. Their main clinically relevant safety risk is statin-induced myopathy (SIM) evidenced clinically as a constellat ...