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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. AAAPT Technology for Improving Chemotherapy

    SBC: Sci-Engi-Medco Solutions, Inc            Topic: NCI

    DESCRIPTION provided by applicant Dysregulation of apoptosis pathways and loss of Human Beta Defensin hBD are the common tactics adapted by cancer cells to circumvent the effects of chemotherapy Consequently high dose of chemotherapy is required to obtain a clinically relevant therapeutic index which in turn compromises safety and develops resistance to therapy The problem is acute p ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. AAV2-ASPA-Based Metabolic Intervention for Alzheimer's Disease

    SBC: ASKLEPIOS BIOPHARMACEUTICAL, INC.            Topic: NIA

    Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. A Bioactive Nanofibrous Sewing Cuff for Treatment of Cardiac Valvular Disease

    SBC: BIOSURFACES, INC.            Topic: NHLBI

    PROJECT SUMMARY Cardiac valve repair or replacement is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting cardiac output. Both procedures require the use of a woven or knitted polyester material with an internal reinforcement (Teflon, silicone or metal) to either stabilize the native valve (annuloplasty r ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. A Biological Small Angle X-ray Scattering Station (BioSAXS) for the Compact Light

    SBC: LYNCEAN TECHNOLOGIES, INC.            Topic: NIGMS

    7. Project Summary/Abstract We propose to develop a Biological Small-angle X-ray Scattering (BioSAXS) station for the Compact Light Source, a powerful new generation of X-ray sources, which will enable biologists and biochemists to pursue state-of-the-artresearch in macromolecular structure studies in their own laboratories. The frontier of structural biology is the determination of large macromol ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. A biomarker of aging as a predictor of kidney transplant function

    SBC: HEALTHSPAN DIAGNOSTICS, LLC            Topic: NIA

    ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD kidneys, obtained primarily from older donors, have a higher risk of delayed graft function and graft loss ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. A Biomimetic Prehensile Digit for Upper-Limb Amputees

    SBC: Invisible Hand Enterprises, LLC            Topic: NICHD

    DESCRIPTION provided by applicant Prostheses reduce the incidence of contralateral overuse syndrome in upper limb amputees by encouraging balanced bimanual limb usage Benefits include reduced pain and muscular atrophy increased productivity and self reliance improved self image a sense of well being and increased social acceptance Body powered prostheses are used extensively in the Uni ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. A Blink-based Communication (BLINC) System for Patients in Bed

    SBC: BARRON ASSOCIATES, INC.            Topic: 600

    DESCRIPTION provided by applicant Introduction The Blink based Communication BLINC System will allow any patient who retains oculomotor control to reliably signal for assistance and communicate basic requests to a caregiver It uses infrared IR cameras and illuminators to continuously monitor a patient in bed and to detect blink signals even in a dark room It is specifically designed so ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Accelerating Wound Healing through RNAi

    SBC: Somagenics, Inc.            Topic: 300

    DESCRIPTION provided by applicant The growing populations of the elderly and those with type II diabetes are at high risk for developing chronic wounds that are slow to heal Effective therapeutics to promote wound healing could significantly improve the lives of these people Normal wound healing involves a coordinated cascade of events that are stimulated in part by the hypoxia that results f ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Accessible Balance and Falls Prevention Exercise Tool Across the Continuum of Car

    SBC: BLUE MARBLE REHAB INC.            Topic: NIA

    DESCRIPTION (provided by applicant): Objective: This Phase 1 SBIR proposes to optimize the interface and interaction of a digital translation of Evidence Based Falls Prevention programs for use across the continuum of care and community living that affordseasy adoption, adherence and monitoring of falls prevention exercises for all stakeholders including those with limited technical experience. Pu ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Access Language Arts

    SBC: Attainment Co., Inc.            Topic: N/A

    Purpose: Instruction in English Language Arts (ELA) for students with severe intellectual disabilities and autism can be challenging, as these students often do not have the skills to engage with text. In recent years, special education experts have proposed a comprehensive approach to supporting students with intellectual disabilities and autism in ELA, centered on strategies including word ident ...

    SBIR Phase II 2014 Department of Education
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