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DESCRIPTION provided by applicant Dysregulation of apoptosis pathways and loss of Human Beta Defensin hBD are the common tactics adapted by cancer cells to circumvent the effects of chemotherapy Consequently high dose of chemotherapy is required to obtain a clinically relevant therapeutic index which in turn compromises safety and develops resistance to therapy The problem is acute p ...

Abstract We propose to initiate preclinical development of a gene therapeutic targeted to Alzheimer's Disease. The World Health Organization's and Alzheimer's Disease International's report on Dementia (2012) recognizes that the global burden of AlzheimerDisease is forecast to worsen significantly with prevalence predicted to double every 20 years. Interventions that could prov ...

PROJECT SUMMARY Cardiac valve repair or replacement is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting cardiac output. Both procedures require the use of a woven or knitted polyester material with an internal reinforcement (Teflon, silicone or metal) to either stabilize the native valve (annuloplasty r ...

7. Project Summary/Abstract We propose to develop a Biological Small-angle X-ray Scattering (BioSAXS) station for the Compact Light Source, a powerful new generation of X-ray sources, which will enable biologists and biochemists to pursue state-of-the-artresearch in macromolecular structure studies in their own laboratories. The frontier of structural biology is the determination of large macromol ...

ABSTRACT The number of kidney transplant candidates on the waiting list continues to increase each year, while the number of kidney donations remains stagnant. The enduring donor shortage compels clinicians to use kidneys from marginal donors, referred toas expanded criteria donors (ECD). ECD kidneys, obtained primarily from older donors, have a higher risk of delayed graft function and graft loss ...

DESCRIPTION provided by applicant Prostheses reduce the incidence of contralateral overuse syndrome in upper limb amputees by encouraging balanced bimanual limb usage Benefits include reduced pain and muscular atrophy increased productivity and self reliance improved self image a sense of well being and increased social acceptance Body powered prostheses are used extensively in the Uni ...

DESCRIPTION provided by applicant Introduction The Blink based Communication BLINC System will allow any patient who retains oculomotor control to reliably signal for assistance and communicate basic requests to a caregiver It uses infrared IR cameras and illuminators to continuously monitor a patient in bed and to detect blink signals even in a dark room It is specifically designed so ...

ABSTRACT: Current composite USAF platforms suffer damage during media blast stripping operations. This is a pervasive issue, with repair being laborious and costly, a material solution is needed to fill in existing damages to the composite skin and provide a protective barrier against future aggregate blasting. NanoSperse proposes to develop a spray-on, flexible, highly erosion resistant polymer ...

Although global pose is essential for success in certain vehicle missions and tasks, when GPS is denied there is no single technology (source) that can robustly estimate global pose without suffering from one or more failure modes. We propose to design an architecture that provides robustness by integrating automated celestial navigation, registering on-board sensor data to a map (map registration ...

TIAX will build, characterize and abuse test lithium-ion cells employing LiCoPO4 cathodes and control metal-oxide based cathodes (such as LiCoO2 ) opposite graphite anodes. In Phase I, TIAX will perform overcharge and external short circuit tests to the specification of the UL1642 standard and will also perform nail penetration tests on both types of cells. In the option program TIAX will perfor ...