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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. MUC4/16 assay for the early diagnosis and management of benign and malignant pancreatic diseases

    SBC: Sanguine Diagnostics And Therapeutics, Inc.            Topic: 300

    Abstract The goal of this Fast track application is to develop a non invasive diagnostic testbased on MUCand MUCmucinsthat can serve as an adjunct to cytological analysis of fine needle aspiratesFNAsfor accurate prediction of malignancy in patients with cystic pancreatic lesionsDue to asymptomatic nature and lack of methods for early detectionandgtof pancreatic cancerPCpatients present with an unr ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Seromic Mucin Signature for the Early Diagnosis of Pancreatic Cancer

    SBC: Sanguine Diagnostics And Therapeutics, Inc.            Topic: 102

    ABSTRACT Pancreatic cancerPCis an extremely aggressive malignancy with one of the worst prognoses of all cancersWith marked resistance to chemoand radiotherapiessurgery is the only curative optionIn patients with localized diseasecomplete surgical resection provides five year survival rate ofHoweverandgtof patients are diagnosed with unresectable primary tumors and or distant metastasisThe major c ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. A Prognostic Blood Test to Monitor Pancreatic Cancer Treatment by MiRNA Profiling

    SBC: VAJRA INSTRUMENTS, INC.            Topic: 102

    Pancreatic ductal adenocarcinomaPDAChas ayear survival rate of less thanThe success in developing therapies for other cancers over the last two decades has not improved the dismal overall survivalOSrate for PDACIt is now becoming increasingly apparent that personalized medicine based on the genetics of a tumor will be essential for developing a treatment strategyThusthere is an urgent need to deve ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Next Generation Western for high-throughput and high-content protein analysis

    SBC: LI-COR, Inc.            Topic: 400

    Abstract The identification and quantification of specific proteins in complex samples are critical processes in discoveringunderstandingand ultimately addressingthe underlying nature of human health and diseaseThe western blot is a fundamental method used for these processes due to the sensitivity and specificity enabled by combining protein sizing with immuno detectionDespite being widelyusedthe ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Mutation Enriched Targeted Re Sequencing

    SBC: TRANSGENOMIC, INC.            Topic: 103

    DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. IMPROVING THE TREATMENT OF CONTAMINATED AQUIFERS BYDEVELOPING DIRECT-PUSH OXIDANT CANDLES WITH PNEUMATIC CIRCULATORS

    SBC: AirLIft Environmental LLC            Topic: NIEHS

    DESCRIPTION provided by applicant Clean water is one of the most basic societal needs in the world Few situations incite more public outcry than when a community learns that their drinking water has been tainted Two of the biggest threats to groundwater quality in the U S are contamination from either chlorinated solvents or petroleum Left unattended the size and scope of the problems asso ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Treatment of Canine Diabetic Cataracts

    SBC: Therapeutic Vision, Inc.            Topic: N

    DESCRIPTION provided by applicant Diabetes mellitus DM in dogs is characterized by a rapid onset of bilateral cataracts that results in vision loss that can only be restored by costly cataract surgery We have developed a topical aldose reductase inhibitor ARI formulation called KinostatTM that prevents the development of diabetic cataracts and thus eliminates the need for cataract surgery ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  8. RADIOGRAPHIC CONTRAST TO DIFFERENTIATE CAVITATED FROM NON-CAVITATED DENTAL CARIES

    SBC: FIREFLY HEALTH INNOVATIONS NE, INC.            Topic: NIDCR

    DESCRIPTION provided by applicant This project aims to improve the accuracy of tests for early tooth decay dental caries specifically for interproximal surfaces where the posterior teeth abut one another In these regions there is no physical space to visually inspect or probe for caries Instead dentists rely on bitewing X rays BWs But dentists cannot tell whether lucencies observed ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Ex Vivo Tolerance for Xenotransplantation of Diabetes P2

    SBC: XIMEREX, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Type I diabetes is a widespread disease in which insulin producing pancreatic islets are lost, leading to unstable glucose levels. If the islets can be replaced, as with transplantation, then diabetes can be reversed.Human islets have limited utility because of a severe shortage of donors and the need for constant immune suppression to prevent rejection. Pigs ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  10. Nanoparticles and Nanocapsules for Glioma Targeting

    SBC: LNKCHEMSOLUTIONS            Topic: NCI

    DESCRIPTION (provided by applicant): Malignant gliomas represent a heterogeneous family of tumors that are poorly responsive to current treatments. A major obstacle to the effective management of these lesions involves the difficulty in delivering adequateconcentrations of therapeutics to the tumor cells. In addition, the inability to image the distribution of therapeutic agent hampers the plannin ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
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