Award Data

ABSTRACT Suicide is a leading cause of death in the US and suicide rates have steadily increased. Despite this, there is a paucity of interventions that reduce suicide ideation and behavior. In this project, we seek to enhance a beta version of our suicide prevention digital therapeutic (developed in phase I) and conduct a randomized controlled trial to evaluate the efficacy of the digital therape ...

ABSTRACT We present a complete platform for the rapid generation and validation of recombinant mAbs. The innovations of this proposal include: (1) the pATHENA vector system for overnight conversion of phage display scFv or Fab clones into IgG molecules, (2) the Epivolve method for the isolation of site-specific Abs, (3) the incorporation of yeast display into pATHENA to allow biophysical measureme ...

BrightSpec Inc. NIH SBIR Application Project Summary Novel Sample Introduction Methodologies for Molecular Rotational Resonance (MRR) Spectroscopy NIH SBIR Direct to Phase II BrightSpec, Inc. Project Summary This project proposes to develop a new analyte sampling technique for Molecular Rotational Resonance (MRR) spectrometers for the volatilization of solid phase analytes. The proposed system, La ...

ABSTRACT Chronic perforations of the tympanic membrane (TM) affect over 170,000 patients in the United States annually, often stemming from ventilation tubes inserted in the TM to drain fluid from middle ear infections. Left untreated, these TM perforations can lead to significant morbidities that include recurrent ear infection, conductive and sensorineural hearing loss, mastoid bone infection, a ...

ABSTRACT Ulcerative colitis (UC) is a chronic, relapsing disease characterized by inflammation and ulceration of the colon and rectum that affects approximately 1.5 million people in the United States.1 Unfortunately, existing therapies have significant limitations. 5-ASA or mesalamine, which is approved as first-line therapy for UC, is effective in only 50% of UC patients and corticosteroids are ...

PROJECT SUMMARY/ABSTRACT Significance: The Knee Biofeedback Rehabilitation Interface for Game-based Home Therapy (“KneeBRIGHT”) system combines electromyography (EMG) biofeedback with video game therapy (VGT) to provide knee osteoarthritis (OA) patients with an engaging, effective tool for conducting rehabilitation exercises at home. KneeBRIGHT aims to motivate OA patients to conduct regular m ...

PD/PI Kennard Brunson Project Summary Toward urinary catheterization with long-term resistance to bacterial colonization Problem: Catheter Associated Urinary Tract Infections (CAUTI) are one of the most common infections in hospitals and health care facilities. A study of urinary catheterisation involving over 9 million hospitalized patients found 12.9% were catheterised overall, but 72.9% were ca ...

PROJECT SUMMARY Opioid use disorder (OUD) is a major contributor to excessive disability, morbidity, and mortality in the United States. Currently, almost 10 million Americans misuse opioid substances and 2.7 million Americans suffer from OUD. In the past year alone, U.S. opioid overdose deaths have increased by nearly 30%, resulting in an annual mortality rate of rt100,000, akin to a death every ...

PROJECT SUMMARY Savior Brain’s SoftShox is the world’s first wearable hydraulic shock absorber. SoftShox uses liquid momentum transfer to dissipate impact energy, resulting in dramatically reduced linear and rotational forces for a given impact event. Brain injuries, including nearly 4 million concussions per year, are common among the nearly 40 million participants in organized youth sports i ...

Tezcat is an early-stage, biopharmaceutical company developing novel biologics with a unique mechanism of action to treat the most recalcitrant cancers, such as mutant RAS multiple myeloma. Multiple myeloma is an incurable hematologic malignancy with an expected median survival of 7-8 years. Despite an initial response rate approaching 90% to proteasome inhibitor- containing combinations, all pati ...