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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. HHSN261201400018C;EPOTHILONE D FORMULATED IN POLYMER MICELLE NANOPARTICLES; POP: 09/17/2014 TO 05/16/2016

    SBC: INTEZYNE TECHNOLOGIES, INC.            Topic: NCI

    This project aims to optimize the lead formulation of epothilone D encapsulated in a stable nanoparticle for the treatment of solid malignancies, and assist in providing for the GMP manufacturing and GLP toxicology studies required for IND submission and translation into human clinical trials. The optimized formulation should demonstrate improvements in plasma pharmacokinetics in a cannulated rat ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. HHSN261201400045CTITLE: SBIR TOPIC 306?ALGORITHMS FOR ANALYSIS OF IN VIVO IMAGES?;TITLE: SBIR TOPIC 306 ENTITLED:?SCALABLE AUTOMATED BRAIN TUMOR SEGMENTATION?;24 MONTHS FUNDING-PHASE II;09/16/2014

    SBC: INFOTECH SOFT, INC.            Topic: NCI

    Not Available

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. RADIOGRAPHIC CONTRAST TO DIFFERENTIATE CAVITATED FROM NON-CAVITATED DENTAL CARIES

    SBC: FIREFLY HEALTH INNOVATIONS NE, INC.            Topic: NIDCR

    DESCRIPTION provided by applicant This project aims to improve the accuracy of tests for early tooth decay dental caries specifically for interproximal surfaces where the posterior teeth abut one another In these regions there is no physical space to visually inspect or probe for caries Instead dentists rely on bitewing X rays BWs But dentists cannot tell whether lucencies observed ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Novel IL-15 Superagonist Therapy for Bladder Cancer

    SBC: Altor Bioscience LLC            Topic: 102

    DESCRIPTION provided by applicant Bladder cancer is the fifth most common cancer in the United States Over of patients initially present with non muscle invasive bladder cancer NMIBC confined to the mucosa of the bladder These patients are treated by tumor resection followed by intravesical chemotherapy or Bacillus Calmette Gu rin BCG therapy Despite treatment of NMIBC pat ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Development of molecular assays for non-invasive bladder cancer detection

    SBC: NONAGEN BIOSCIENCE CORPORATION            Topic: 102

    DESCRIPTION provided by applicant Bladder cancer BCa is among the five most common malignancies worldwide In the US alone new BCa cases for are estimated at with estimated deaths at At presentation the majority of bladder tumors are non muscle invasive and can be treated by transurethral resection of the tumor however more than of patients with BCa will have a re ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a WNT Inhibitor for Advanced Stage Lung Cancer

    SBC: Stemsynergy Therapeutic            Topic: 102

    DESCRIPTION provided by applicant Non small cell lung cancer NSCLC is the most common lung cancer Half of NSCLC shows WNT activation marking poor survival StemSynergy Therapeutics Inc SSTI has identified a family of WNT inhibitors based on a novel chemical scaffold with our lead molecule SST demonstrating efficacy against WNT driven colorectal cancer In Phase I SBIR studies many ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. IL-15 Superagonist Complex as an Immunotherapeutic for Multiple Myeloma

    SBC: Altor Bioscience LLC            Topic: 102

    DESCRIPTION provided by applicant Multiple myeloma MM is the second most commonly diagnosed hematologic malignancy with an estimated newly diagnosed cases and deaths due to MM in the United States in MM typically a disease of the elderly is a malignancy of clonal plasma cells in the bone marrow BM characterized by the presence of paraproteinemia destructive bone dise ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Smart Capsule for Automatic Adherence Monitoring

    SBC: ETECT, INC.            Topic: R44

    DESCRIPTION provided by applicant Poor medication adherence has a significant negative impact on patients clinical study outcomes and the healthcare system in general As much as of all healthcare costs could be avoided if patients reliably took their prescribed medications Medication adherence is of particular concern in clinical trials Standard measures of adherence pill counting and ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Bone Conduction Testing for Newborn Hearing Screening

    SBC: Intelligent Hearing Systems Corp.            Topic: NIDCD

    DESCRIPTION provided by applicant This study aims to develop an improved neonatal hearing screening device that will incorporate novel testing procedures combining simultaneous air and bone conduction testing so that mild hearing losses andlt dB nHL are better and consistently detected The proposed device will address the current need for a more sensitive hearing screening tool by stimul ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Oxalate Reduction by Oral Administration of Oxalate Degrading Enzymes

    SBC: CAPTOZYME LLC            Topic: 400

    DESCRIPTION provided by applicant Severe oxalate related conditions such as primary hyperoxaluria PH secondary hyperoxaluria SH as a result of short bowel syndrome chronic inflammatory bowel disease cystic fibrosis post bariatric and other malabsorption syndromes Zellweger spectrum disorders ZSD and chronic and end stage renal failure continues to be a healthcare problem without ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
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