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DESCRIPTION provided by applicant Sarcopenia defined as age related loss of muscle mass and muscle function and strength is very prevalent among the elderly Sarcopenia is one of the largest public health problems facing a rapidly increasing aging population in the United States and leads to increased incidence of falls fractures and associated morbidities Previous observations from our la ...

DESCRIPTIONprovided by applicantDuchenne muscular dystrophyDMDis an X linked recessive disorder caused by mutations in the DMD gene with a prevalence ofinmale birthsThe consequent loss of functional dystrophin results in the progressive degeneration of skeletal and cardiac muscleDespite significant progress in our understanding of this disease and advances in the development of new therapeutic app ...

? DESCRIPTION (provided by applicant): Manual drug compounding of chemotherapy medications permits deadly dosing errors and toxic drug exposure and therefore poses unnecessary risks to patients and healthcare professionals. Some robotic compounding devices have been developed in response; however, poor drug containment safety capabilities and prohibitive cost and size have limited widespread a ...

DESCRIPTION (provided by applicant): The specific aim of this Phase IIb (Phase II competitive renewal) SBIR proposal is to advance the prototype systems we developed under our Phase II grant into commercial production. Our product will be used to automatically track samples in laboratory and biobank freezers. Most of these samples are stored in vials. Between 200 and 500 million such vials are ...

DESCRIPTION provided by applicant B cell lymphoma is cancer of B lymphocytes and accounts for more than deaths in the U S each year While many patients respond to currently available therapy there is a high rate of cancer relapse and inability for the patients o tolerate chemotherapy Thus there is a significant need to make available to these patients newer therapies that are more e ...

DESCRIPTION provided by applicant This project aims to improve the accuracy of tests for early tooth decay dental caries specifically for interproximal surfaces where the posterior teeth abut one another In these regions there is no physical space to visually inspect or probe for caries Instead dentists rely on bitewing X rays BWs But dentists cannot tell whether lucencies observed ...

DESCRIPTION provided by applicant Abstract This project consists of the continued development of a unique implantable ischemia monitor that uses subcutaneous sensors in the patientandapos s torso to detect the onset of acute myocardial infarction AMI Upon detecting a heart attack the monitor generates an alarm which enables the patient to promptly seek medical treatment In the United Stat ...